Viewing Study NCT05314881



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Last Modification Date: 2024-10-26 @ 2:29 PM
Study NCT ID: NCT05314881
Status: UNKNOWN
Last Update Posted: 2022-04-06
First Post: 2022-03-26

Brief Title: NCF Gene TNFSF4 in SLE Patients
Sponsor: Assiut University
Organization: Assiut University

Study Overview

Official Title: Polymorphisms of the Tumor Necrosis Factor Superfamily 4 and Neutrophil Cytosolic Factor Gene in SLE Egyptian Patients
Status: UNKNOWN
Status Verified Date: 2022-04
Last Known Status: NOT_YET_RECRUITING
Delayed Posting: No
If Stopped, Why?: Not Stopped
Has Expanded Access: False
If Expanded Access, NCT#: N/A
Has Expanded Access, NCT# Status: N/A
Acronym: None
Brief Summary: the investigators objective is to identify the association of SNP polymorphisms in the TNFS4 and NCF gene and SLE Egyptian patients
Detailed Description: Systemic lupus erythematosus SLE is a chronic autoimmune disease characterized by clinical heterogeneity with variable severity Among the SLE patients two may share the same clinical manifestations but have different phenotypes

This is why studies are searching for the different genes that might be associated with SLE susceptibility

The Neutrophil cytosolic factor NCF Gene provide the instruction for the synthesis of group of proteins that form the NADPH oxidase enzyme complex that is critical for the induction of reactive oxygen species ROS which in turn is important in the regulation of immune system

While the Tumor necrosis factor superfamily 4 TNFSF4 encodes the ligand for OX40 OX40L which delivers a strong costimulatory signal to activated effector T-cells and enhances both Th1 and Th2 responses when engaged with its receptor Therefore increased levels of cell surface OX40L may augment B cell differentiation and proliferation The consequence of which is that the resulting autoantibodies and immune complexes cause disease pathology in SLE

So NCF and TNFSF4 gene polymorphism are supposed to be associated with SLE risk and pathophysiology

Study Oversight

Has Oversight DMC: None
Is a FDA Regulated Drug?: False
Is a FDA Regulated Device?: False
Is an Unapproved Device?: None
Is a PPSD?: None
Is a US Export?: None
Is an FDA AA801 Violation?: None