Ignite Creation Date:
2024-05-05 @ 5:34 PM
Last Modification Date:
2024-10-26 @ 9:33 AM
Study NCT ID:
NCT00482872
Status:
COMPLETED
Last Update Posted:
2017-03-14
First Post:
2007-06-04
Brief Title:
Germline Mutations in Patients With Head and Neck Cancer and a Family History of Cancer
Sponsor:
Vanderbilt University Medical Center
Organization:
Vanderbilt University Medical Center
Study Overview
Official Title:
Familial HNSCC Syndrome and p16 Germline Mutations
Status:
COMPLETED
Status Verified Date:
2017-03
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
RATIONALE Studying gene mutations in samples of DNA from patients with head and neck cancer and a family history of cancer may help doctors learn more about the development of cancer in families
PURPOSE This clinical trial is studying germline mutations in patients with head and neck cancer and a family history of cancer
PURPOSE This clinical trial is studying germline mutations in patients with head and neck cancer and a family history of cancer
Detailed Description:
OBJECTIVES
Measure the incidence of p16INK4a germline mutations in patients with squamous cell carcinoma of the head and neck and a family history of cancer
Determine biologic activity of identified p16INK4a germline mutations
OUTLINE DNA specimens are collected for genetic and mutation analysis and examined by PCR and flow cytometry The activity of cells with p16 mutations is determined by cell cycle arrest functional assay
Measure the incidence of p16INK4a germline mutations in patients with squamous cell carcinoma of the head and neck and a family history of cancer
Determine biologic activity of identified p16INK4a germline mutations
OUTLINE DNA specimens are collected for genetic and mutation analysis and examined by PCR and flow cytometry The activity of cells with p16 mutations is determined by cell cycle arrest functional assay
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| P30CA068485 | NIH | None | None |
| VU-VICC-HN-0402 | None | None | None |
| VICC-IRB-040030 | US NIH GrantContract | None | httpsreporternihgovquickSearchP30CA068485 |