Ignite Creation Date:
2024-05-05 @ 5:33 PM
Last Modification Date:
2024-10-26 @ 9:33 AM
Study NCT ID:
NCT00482924
Status:
UNKNOWN
Last Update Posted:
2021-09-22
First Post:
2007-06-04
Brief Title:
Observational Study of Early Metabolic and Vascular Changes in Obesity
Sponsor:
Medical University of Graz
Organization:
Medical University of Graz
Study Overview
Official Title:
Study for the Investigation of New Individual Risk Profiles and Therapeutic Strategies in Obesity Related Cardiovascular and Metabolic Disorders
Status:
UNKNOWN
Status Verified Date:
2021-09
Last Known Status:
RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
STYJOBS
Brief Summary:
To work against the increasing burden of obesity the STYJOBS EDECTA STYrian Juvenile OBesity Study Early DetECtion of Atherosclerosis project was started at the Medical University of Graz in 2003 STYJOBS EDECTA is a prospective observational study to improve the understanding of atherosclerosis cardiovascular risk immune mediated low grade Inflammation metabolic changes and general disease propensity in obesity The investigation of the non-biased early phase is strongly focused
Based on this information new and effective strategies for preclinical diagnostics and early intervention are of main interest We seek a better understanding of critical lipid profiles chronic immune-mediated inflammation disturbed adipokine balance critical adipose tissue topography addiction like behaviour geneticsepigenetics early vascular pathology and fatty liver disease Interventional branches of study tested a holistic strategy comprehending sports and lifestyle modification for efficiency The investigative spectrum of STYJOBS EDECTA comprehends also non-obese body weight extremes ie underweightanorectic people
Based on this information new and effective strategies for preclinical diagnostics and early intervention are of main interest We seek a better understanding of critical lipid profiles chronic immune-mediated inflammation disturbed adipokine balance critical adipose tissue topography addiction like behaviour geneticsepigenetics early vascular pathology and fatty liver disease Interventional branches of study tested a holistic strategy comprehending sports and lifestyle modification for efficiency The investigative spectrum of STYJOBS EDECTA comprehends also non-obese body weight extremes ie underweightanorectic people
Detailed Description:
Obesity is dramatically increasing in countries with so called western Lifestyle whereby juveniles are affected in particular Atherosclerosis a major consequence of obesity starts early in life and results in cardiovascular disease and stroke the main causes of mortality in industrialized countries STYJOBS EDECTA is a prospective observational study to improve the understanding of obesity associated pathologic conditions by investigation of the non-biased early phase
We aim
To identify individual metabolic high risk patterns in obesity by linking lab parameters adipokines immune-inflammatory mediators oxidative stress biomarkers lipoproteins molecular genetics epigenetics individual adipose tissue topography early vascular damage life style habits and clinical data
The STYJOBSEDECTA-Database comprehends currently data from 1325 subjectsFor each proband 282 variables are available Clinical anthropometric carotis IMT 82 LaboratoryBiomarkers 100 Glucose metabolism liver kidney function lipids oxidativenitrosative stress adipokines gut-brain axis clotting Geneticmitochondrial functionmiscellaneous100 and the results of an early interventional trial by a holistic strategy
To establish a comprehensive biobank The STYJOBSEDECTA-biomaterial resource comprises serumplasmaDNA left over probes from currently 1256 probands
EDECTA Early DEteCTion of Atherosclerosis extends the STYJOBS Database and Bioresource with normal weight and obese probands aged up to 80 years
To improve the understanding of craving and addiction like behaviour in obesity eglink insulin resistance - control of hedonic inputs
Thus the STYJOBS EDECTA resource comprises in extendo data and biomaterial specimen from subjects afflicted with the preclinical phase of major sequels of obesity such as insulin resistance cardiovascular disease and probably also certain sorts of cancer
To further improve the understanding of dysbalanced energy expenditure in obesity mitochondrial haplotypes are investigated in cooperation with DrWeghuber DrEder and ProfSperl from the Salzburg Paracelsus Private Medical School All genetic and epigenetic measurements are performed by an anonymous approach data privacy protection after careful accreditation by the local ethical committee
The investigative spectrum of STYJOBS EDECTA is also extended to underweightanorectic people This condition is an attractive biologic counterpart to the overweightobese group Extremely underweight and anorectic patients are afflicted with profound metabolic abnormalities Thus it is interesting to investigate anorexia associated risk profiles in comparison to those found in overweightobese people Especially the craving like behaviour and the cardiovascularoxStress risk will be focused in our investigations
Further we investigate the role of tryptophan TRP metabolism in context with obesity immune-mediated inflammation skewing of T helper cells and mechanisms underlying uncontrolled overeating
We aim
To identify individual metabolic high risk patterns in obesity by linking lab parameters adipokines immune-inflammatory mediators oxidative stress biomarkers lipoproteins molecular genetics epigenetics individual adipose tissue topography early vascular damage life style habits and clinical data
The STYJOBSEDECTA-Database comprehends currently data from 1325 subjectsFor each proband 282 variables are available Clinical anthropometric carotis IMT 82 LaboratoryBiomarkers 100 Glucose metabolism liver kidney function lipids oxidativenitrosative stress adipokines gut-brain axis clotting Geneticmitochondrial functionmiscellaneous100 and the results of an early interventional trial by a holistic strategy
To establish a comprehensive biobank The STYJOBSEDECTA-biomaterial resource comprises serumplasmaDNA left over probes from currently 1256 probands
EDECTA Early DEteCTion of Atherosclerosis extends the STYJOBS Database and Bioresource with normal weight and obese probands aged up to 80 years
To improve the understanding of craving and addiction like behaviour in obesity eglink insulin resistance - control of hedonic inputs
Thus the STYJOBS EDECTA resource comprises in extendo data and biomaterial specimen from subjects afflicted with the preclinical phase of major sequels of obesity such as insulin resistance cardiovascular disease and probably also certain sorts of cancer
To further improve the understanding of dysbalanced energy expenditure in obesity mitochondrial haplotypes are investigated in cooperation with DrWeghuber DrEder and ProfSperl from the Salzburg Paracelsus Private Medical School All genetic and epigenetic measurements are performed by an anonymous approach data privacy protection after careful accreditation by the local ethical committee
The investigative spectrum of STYJOBS EDECTA is also extended to underweightanorectic people This condition is an attractive biologic counterpart to the overweightobese group Extremely underweight and anorectic patients are afflicted with profound metabolic abnormalities Thus it is interesting to investigate anorexia associated risk profiles in comparison to those found in overweightobese people Especially the craving like behaviour and the cardiovascularoxStress risk will be focused in our investigations
Further we investigate the role of tryptophan TRP metabolism in context with obesity immune-mediated inflammation skewing of T helper cells and mechanisms underlying uncontrolled overeating
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None