Ignite Creation Date:
2024-05-06 @ 5:15 PM
Last Modification Date:
2024-10-26 @ 2:25 PM
Study NCT ID:
NCT05242354
Status:
COMPLETED
Last Update Posted:
2023-05-18
First Post:
2022-01-28
Brief Title:
Macrophage Markers in Periodontal and Peri-implant Health and Disease
Sponsor:
Biruni University
Organization:
Biruni University
Study Overview
Official Title:
CD80 CD163 and CD206 Tissue Levels in Periodontal and Peri-implant Health and Disease
Status:
COMPLETED
Status Verified Date:
2023-05
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Macrophage surface markers CD80 CD163 and CD206 will be evaluated in periodontally healthy gingiva healthy peri-implant mucosa and periodontitis and peri-implantitis lesions
Detailed Description:
Soft tissue biopsies obtained from clinically healthy gingiva healthy peri-implant mucosa Stage III Grade C periodontitis lesions and peri-implantitis lesions will be evaluated
Healthy peri-implant samples are obtained from submerged implants during exposure surgery Healthy gingiva samples are obtained from individuals receiving crown lengthening gingivectomy or tooth extraction as excess tissue during the corresponding treatment Samples from peri-implantitis and periodontitis pocket depth 6 mm bleeding on probing are obtained during initial periodontal treatment debridement procedure with a single stroke at the pocket wall
The samples will be grinded and ultrasonicated Western blotting will be used for determination of CD80 CD163 and CD206 in biopsy specimens ImageJ will be used for intensity analysis of the bands
Healthy peri-implant samples are obtained from submerged implants during exposure surgery Healthy gingiva samples are obtained from individuals receiving crown lengthening gingivectomy or tooth extraction as excess tissue during the corresponding treatment Samples from peri-implantitis and periodontitis pocket depth 6 mm bleeding on probing are obtained during initial periodontal treatment debridement procedure with a single stroke at the pocket wall
The samples will be grinded and ultrasonicated Western blotting will be used for determination of CD80 CD163 and CD206 in biopsy specimens ImageJ will be used for intensity analysis of the bands
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None