Ignite Creation Date:
2024-05-06 @ 5:15 PM
Last Modification Date:
2024-10-26 @ 2:25 PM
Study NCT ID:
NCT05242705
Status:
NOT_YET_RECRUITING
Last Update Posted:
2022-03-08
First Post:
2022-02-07
Brief Title:
Serum Cysteine Rich Protein 61 and Cystatin C for Early Detection of Acute Kidney Injury in Patients With Heart Diseases
Sponsor:
Assiut University
Organization:
Assiut University
Study Overview
Official Title:
Serum Cysteine Rich Protein 61 and Cystatin C for Early Detection of Acute Kidney Injury in Patients With Acute Coronary Syndromes
Status:
NOT_YET_RECRUITING
Status Verified Date:
2022-02
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Acute Kidney Injury AKI is defined as an absolute increase in serum creatinine 03 mgdl 264 μmoll a percentage increase in serum creatinine 50 15-fold from baseline or a reduction in urine output documented oliguria 05 mlkghour for 6 hours Screatinine which is considered the gold standard currently for diagnosis of AKI remains unchanged until 50 of kidney function falls down It is affected by non-specific factors like diet age dehydration muscle mass gender and drugs
There were evidences of the association between AKI and acute coronary syndrome ACS First AKI detection may be missed by cardiologists Physicians tend to disregard mild or transient serum creatinine elevation during hospital stay for ACS and they often attribute small serum creatinine increases to laboratory variations
There were evidences of the association between AKI and acute coronary syndrome ACS First AKI detection may be missed by cardiologists Physicians tend to disregard mild or transient serum creatinine elevation during hospital stay for ACS and they often attribute small serum creatinine increases to laboratory variations
Detailed Description:
Cystatin C CysC a cystatin protease inhibitor is less affected by non-specific factors When glomerular filtration rate GFR decreases CysC begins to increase
CysC was recommended to be measured in addition to creatinine in GFR estimation
Cysteine-rich protein 61 Cyr61 is a cysteine-rich secretory protein that promotes cell proliferation adhesion chemotaxis embryonic development and neovascularization Previous studies have detected low expression level of Cyr61 in normal adult kidney and high expression of Cyr61 in ischemic rats and mice kidney which suggests that Cyr61 may be a potential biomarker for diagnosis of AKI CYR61 might possibly identify patients with more severe kidney injury which would be very beneficial for early treatment of AKI after
CysC was recommended to be measured in addition to creatinine in GFR estimation
Cysteine-rich protein 61 Cyr61 is a cysteine-rich secretory protein that promotes cell proliferation adhesion chemotaxis embryonic development and neovascularization Previous studies have detected low expression level of Cyr61 in normal adult kidney and high expression of Cyr61 in ischemic rats and mice kidney which suggests that Cyr61 may be a potential biomarker for diagnosis of AKI CYR61 might possibly identify patients with more severe kidney injury which would be very beneficial for early treatment of AKI after
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None