Ignite Creation Date:
2024-05-05 @ 11:20 AM
Last Modification Date:
2024-10-26 @ 9:02 AM
Study NCT ID:
NCT00001064
Status:
TERMINATED
Last Update Posted:
2016-12-14
First Post:
1999-11-02
Brief Title:
A Pilot Study of Immunization With HIV-1 Antigen Pulsed Allogenic Dendritic Cells in HIV-Infected Asymptomatic Patients With CD4 T Cells 350 Cellsmm3
Sponsor:
National Institute of Allergy and Infectious Diseases NIAID
Organization:
National Institute of Allergy and Infectious Diseases NIAID
Study Overview
Official Title:
A Pilot Study of Immunization With HIV-1 Antigen Pulsed Allogenic Dendritic Cells in HIV-Infected Asymptomatic Patients With CD4 T Cells 350 Cellsmm3
Status:
TERMINATED
Status Verified Date:
1995-04
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
To define the safety and efficacy of sibling-supplied HIV antigen-pulsed dendritic cells in increasing the immune response in HIV-infected patients
Dendritic cells are a type of white blood cell used by the body to fight infection They are instrumental in presenting antigens such as HIV antigens to the bodys immune system Since dendritic cells are not functioning maximally in HIV-infected patients infusion of dendritic cells from an HIV-negative sibling may enable the affected siblings immune system to recognize foreign particles more readily and increase immune response against the virus
Dendritic cells are a type of white blood cell used by the body to fight infection They are instrumental in presenting antigens such as HIV antigens to the bodys immune system Since dendritic cells are not functioning maximally in HIV-infected patients infusion of dendritic cells from an HIV-negative sibling may enable the affected siblings immune system to recognize foreign particles more readily and increase immune response against the virus
Detailed Description:
Dendritic cells are a type of white blood cell used by the body to fight infection They are instrumental in presenting antigens such as HIV antigens to the bodys immune system Since dendritic cells are not functioning maximally in HIV-infected patients infusion of dendritic cells from an HIV-negative sibling may enable the affected siblings immune system to recognize foreign particles more readily and increase immune response against the virus
Dendritic cells from an HIV-negative sibling are obtained and treated with various viral proteins HIV vaccines or immunomodulators The treated dendritic cells are infused into the HIV-infected patient monthly for 6 months Siblings must be able to donate on multiple occasions and patients are followed every 2-4 weeks during the study Patients are screened over 3 months prior to study entry
Dendritic cells from an HIV-negative sibling are obtained and treated with various viral proteins HIV vaccines or immunomodulators The treated dendritic cells are infused into the HIV-infected patient monthly for 6 months Siblings must be able to donate on multiple occasions and patients are followed every 2-4 weeks during the study Patients are screened over 3 months prior to study entry
Study Oversight
Has Oversight DMC:
Is a FDA Regulated Drug?:
Is a FDA Regulated Device?:
Is an Unapproved Device?:
Is a PPSD?:
Is a US Export?:
Is an FDA AA801 Violation?: