Ignite Creation Date:
2024-05-06 @ 5:14 PM
Last Modification Date:
2024-10-26 @ 2:24 PM
Study NCT ID:
NCT05232357
Status:
UNKNOWN
Last Update Posted:
2022-03-15
First Post:
2022-01-05
Brief Title:
Endoscopic Vital Nerve Staining in Gastrointestinal Diseases
Sponsor:
Affiliated Hospital to Academy of Military Medical Sciences
Organization:
Affiliated Hospital to Academy of Military Medical Sciences
Study Overview
Official Title:
In Vivo Evaluation of Tumor Neurogenesis in Gastrointestinal Diseases by Topical Submucosal Chromoendoscopy
Status:
UNKNOWN
Status Verified Date:
2022-02
Last Known Status:
RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
In this study methylene blue MB was used as vital nerve staining agent During gastroenteroscopy mucosal nerve staining was achieved by endoscopic submucosal injection of MB solution To observe the staining of nerve fibers neurons and glial cells in mucosa and submucosa as well as the morphological changes density differences and function of mucosal nerve tissues in different gastrointestinal lesions in order to explore the role of endoscopic vital nerve staining in the diagnosis of gastrointestinal lesions
Detailed Description:
This study is a prospective experimental study The baseline data of the patients were recorded objectively sex age vital signs body weight some laboratory examination results blood routine liver function blood coagulation function and electrolytes etc and related medical history comorbidities treatment history and life history Mucosal nerve staining was achieved by endoscopic submucosal injection of methylene blue MB solution The following features were identified and then compared between normal adenoma and neoplastic mucosa on magnifying endoscopy images in vivo nerve morphology straight or irregular nerve diameter branching patterns and nerve density Immunohistochemistry was used to further confirm the presence and to study the morphology of neural structures PGP95 and GFAP staining and neural attribute VIP nNOS TH ChAT and SOM staining on tumor adenoma and normal mucosal sectionsThe aim of this study was to explore the role of MB based topical submucosal chromoendoscopy in the identification of neural architecture and special morphology in normal gastrointestinal mucosa adenomas and malignant lesions during routine endoscopy
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None