Viewing Study NCT05232500



Ignite Creation Date: 2024-05-06 @ 5:13 PM
Last Modification Date: 2024-10-26 @ 2:24 PM
Study NCT ID: NCT05232500
Status: NOT_YET_RECRUITING
Last Update Posted: 2023-09-13
First Post: 2022-02-01

Brief Title: Contribution of a High-resolution Diffusion Sequence at 3T for the Detection of Acute Punctate Ischemic Brain Lesions
Sponsor: Fondation Hôpital Saint-Joseph
Organization: Fondation Hôpital Saint-Joseph

Study Overview

Official Title: Contribution of a High-resolution Diffusion Sequence at 3T for the Detection of Acute Punctate Ischemic Brain Lesions
Status: NOT_YET_RECRUITING
Status Verified Date: 2023-09
Last Known Status: None
Delayed Posting: No
If Stopped, Why?: Not Stopped
Has Expanded Access: False
If Expanded Access, NCT#: N/A
Has Expanded Access, NCT# Status: N/A
Acronym: STROKE_HR
Brief Summary: Stroke is a public health issue and a priority for our institution MRI plays an essential role in the management of stroke its contribution being diagnostic etiological and prognostic

Among the MRI sequences used in stroke emergencies the diffusion sequence plays a key role in highlighting ischemic lesions as early as the hyperacute phase even though the other sequences in the protocol do not reveal any anomaly This sequence alone conditions the management of patients particularly in the context of thrombolysis emergencies

It has been shown that the sensitivity of the diffusion sequence for the detection of ischemic lesions can directly depend on acquisition parameters such as b value slice thickness or spatial resolution

Recent advances in MRI now allow us to perform diffusion sequences with higher spatial resolution The matrix is an important acquisition parameter of MRI sequences defining the ability of the sequence to distinguish 2 pixels in the acquisition plane The higher the matrix the higher the spatial resolution of the sequence in the acquisition plane

At the Saint-Joseph Hospital we have a new 3T MRI since September 2020 allowing the acquisition in clinical routine of a more resolved diffusion sequence 160x200 matrix high resolution diffusion HR against 128x140 standard diffusion usually These two sequences are acquired in particularly short acquisition times 1 minute 37 seconds This HR diffusion sequence is performed as part of routine care since September 2020 for specific situations absence of lesion highlighted on the standard diffusion sequence while the patient has a suggestive symptomatology especially for lesions of the brainstem search for lesion in other vascular territories thus in favor of an embolic origin in a patient who presents an isolated ischemic lesion or ischemic lesions in a single territory

It has been reported in the literature that increasing the spatial resolution can reveal small lesions that were not visible on more conventional sequences There is a clear rationale for seeking to improve the detection of small lesions 5 mm because their detection may have important therapeutic implications for many patients particularly in the context of thrombolysis emergencies transient ischemic attacks or amnesic strokes
Detailed Description: None

Study Oversight

Has Oversight DMC: None
Is a FDA Regulated Drug?: False
Is a FDA Regulated Device?: False
Is an Unapproved Device?: None
Is a PPSD?: None
Is a US Export?: None
Is an FDA AA801 Violation?: None