Ignite Creation Date:
2024-05-05 @ 5:33 PM
Last Modification Date:
2024-10-26 @ 9:33 AM
Study NCT ID:
NCT00478543
Status:
COMPLETED
Last Update Posted:
2009-02-04
First Post:
2007-05-24
Brief Title:
Loop Diuretics in Chronic Kidney Disease
Sponsor:
University of Campania Luigi Vanvitelli
Organization:
University of Campania Luigi Vanvitelli
Study Overview
Official Title:
Effect of Loop Diuretics Treatment on Blood Pressure Control in Phase 3-4 of Chronic Kidney Disease
Status:
COMPLETED
Status Verified Date:
2009-02
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The purpose of this study is to verify the efficacy of diuretic therapy on blood pressure control and left ventricular mass in patients affected by chronic kidney disease
Detailed Description:
In CKD impairment of renal function causes fluid and sodium retention and consequently expansion of extracellular volume which corresponds to about 5 of body weight in absence of peripheral edema In particular sodium retention increases exponentially as glomerular filtration rate declines and is of primary importance in the pathogenesis of hypertension Therefore reduction of salt intake in renal patients allows a better blood pressure control Despite the evidence collected on the beneficial effects of salt restriction in CKD compliance with dietary prescription is generally poor in patients followed up in the real world of clinical practice In the presence of poor adherence to salt restriction diuretics agents become the cornerstone of treatment of hypertension secondary to CKD Disappointingly nephrologists are reluctant to adequately use loop diuretics in their hypertensive CKD patients probably because of the fear of side effects and of the amazing absence in medical literature of studies of middle-long term on diuretic efficacy Therefore the primary aim of this study is to evaluate efficacy and safety of loop diuretics on blood pressure control in patients affected by CKD
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None