Ignite Creation Date:
2024-05-05 @ 5:33 PM
Last Modification Date:
2024-10-26 @ 9:32 AM
Study NCT ID:
NCT00473733
Status:
UNKNOWN
Last Update Posted:
2007-05-15
First Post:
2007-05-13
Brief Title:
Glucagon Like Peptides Receptors Expression in the Stomach of Diabetes Type 2
Sponsor:
Assaf-Harofeh Medical Center
Organization:
Assaf-Harofeh Medical Center
Study Overview
Official Title:
None
Status:
UNKNOWN
Status Verified Date:
2007-04
Last Known Status:
NOT_YET_RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
GLP
Brief Summary:
Glucagon like peptides receptors expression in the stomach of diabetes type 2 Glucagon like peptides GLP-1 GLP-2 are hormones secreted by L cells located along the gastrointestinal tract These hormones are secreted after meals and have some roles in regulating the digestion process absorption and sending signals to the brain that regulate food consumption GLP peptides affect peripheral targets and have an important homeostatic role GLP-1 decreases the circulatory glucose level and GLP-2 has trophic effects which enable adequate intestine growth
We aimed in our study to investigate the GLP-1 and GLP-2 receptor expression in different zones of the stomach in diabetes type 2 patients If there are differences it might explain the pathological gastric emptying in these patients
Understanding the function of these peptides may lead to new therapeutic options for diabetic patients with delayed gastric emptying
Methods 20 diabetes type 2 patients with symptoms that need upper endoscopy will be included in the study and 20 controls aged 18-70 years Patients with neurological disease will be excluded During esophagogastroduodenoscopy 3 biopsies will be taken from the antrum corpus and cardia The biopsies will be stored in -70 After RNA extraction the GLP receptors expression will established by real time PCR method Patients with different expression compared to control will undergo isotopic scan for gastric emptying
We aimed in our study to investigate the GLP-1 and GLP-2 receptor expression in different zones of the stomach in diabetes type 2 patients If there are differences it might explain the pathological gastric emptying in these patients
Understanding the function of these peptides may lead to new therapeutic options for diabetic patients with delayed gastric emptying
Methods 20 diabetes type 2 patients with symptoms that need upper endoscopy will be included in the study and 20 controls aged 18-70 years Patients with neurological disease will be excluded During esophagogastroduodenoscopy 3 biopsies will be taken from the antrum corpus and cardia The biopsies will be stored in -70 After RNA extraction the GLP receptors expression will established by real time PCR method Patients with different expression compared to control will undergo isotopic scan for gastric emptying
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None