Ignite Creation Date:
2024-05-06 @ 5:12 PM
Last Modification Date:
2024-10-26 @ 2:24 PM
Study NCT ID:
NCT05231915
Status:
RECRUITING
Last Update Posted:
2023-10-17
First Post:
2022-02-01
Brief Title:
Prevalence of the c853delT Mutation of the HOXB13 Gene in Prostate Cancer in Martinique
Sponsor:
University Hospital Center of Martinique
Organization:
University Hospital Center of Martinique
Study Overview
Official Title:
Prevalence of the c853delT Mutation of the HOXB13 Gene in Prostate Cancer in Martinique
Status:
RECRUITING
Status Verified Date:
2024-08
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
HOXB13_Mart
Brief Summary:
In Martinique prostate cancer incidence rates are nowadays among the highest worldwide with a high incidence of early-onset and familial forms We identified a rare heterozygous germline variant c853delT pTer285Lysfs rs77179853 reported only among patients of African ancestry with a minor allele frequency of 32 We search to estimate the prevalence of this variant in a sample of prevalent prostate cancer cases managed in urology consultation in Martinique
Detailed Description:
In Martinique prostate cancer incidence rates are nowadays among the highest worldwide with a high incidence of early-onset and familial forms Despite the demonstration of a strong familial component identification of the genetic basis for hereditary prostate cancer is challenging The screening of the HOXB13 gene is recommended for men who develop an early-onset andor familial Pca In fact the HOXB13 germline variant G84E rs138213197 was described in men of European descent with prostate cancer risk Other germline variants were detected in ethnic groups More recently we reported a rare HOXB13 mutation specifically c853delT pTer285Lysfs that appears to be contribute to young Prostate Cancer cases in Martinique This variant is a stop loss reported only among patients of African ancestry
Regarding the allele frequency of the HOXB13 c853delT variant observed in the Pca cohort it will be necessary to assess relative and absolute Pca risks for HOXB13 c853delT carriers This information is essential to use this variant in genetic counseling We propose to sequence the HOXB13 gene of all prostate cancers cases managed in urology consultation in Martinique
Regarding the allele frequency of the HOXB13 c853delT variant observed in the Pca cohort it will be necessary to assess relative and absolute Pca risks for HOXB13 c853delT carriers This information is essential to use this variant in genetic counseling We propose to sequence the HOXB13 gene of all prostate cancers cases managed in urology consultation in Martinique
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None