Ignite Creation Date:
2024-05-05 @ 5:32 PM
Last Modification Date:
2024-10-26 @ 9:33 AM
Study NCT ID:
NCT00475891
Status:
COMPLETED
Last Update Posted:
2014-12-08
First Post:
2007-05-17
Brief Title:
Determination of Genetic Relatedness of Linezolid-resistant Vancomycin-resistant Enterococci VRE Surveillance Cultures
Sponsor:
University of Pittsburgh
Organization:
University of Pittsburgh
Study Overview
Official Title:
Determination of Genetic Relatedness of Linezolid-resistant Vancomycin-resistant Enterococci VRE Surveillance Cultures
Status:
COMPLETED
Status Verified Date:
2014-12
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The study will help in identifying the best empiric antibiotic option for Linezolid resistant Vancomycin-resistant Enterococci VRE infections This research is important because it allows the determination of resistance rates to antibiotics that may not be frequently tested to by the clinical microbiology laboratory at UPMC-Presbyterian It also will provide antibiotic minimum inhibitory concentrations MICs for these pathogens which may help in identifying the best empiric antibiotic option for Linezolid-resistant VRE infections
Detailed Description:
After 20 linezolid-resistant VRE isolates are identified genetic relatedness will be determined using a method known as Pulse-field gel electrophoresis PFGE No patient related data will accompany these isolates nor will any related identifiers These isolates will be tested using standardized susceptibility methods We will then grow each isolate and test via approved laboratory standards E-test AB Biodisk Stockholm Sweden to the drug linezolid Those determined to be resistant using this approved methodology will be saved until 20 isolates are identified For resistant isolates found analytical and molecular techniques will be performed to determine the mechanisms of resistance and whether resistant isolates are coming from a single sourcebeing transmitted from person to person
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None