Ignite Creation Date:
2024-05-05 @ 5:32 PM
Last Modification Date:
2024-10-26 @ 9:33 AM
Study NCT ID:
NCT00474279
Status:
COMPLETED
Last Update Posted:
2007-05-16
First Post:
2007-05-15
Brief Title:
Effects of an Oral GH Secretagogue MK-677 on Body Composition and Functional Ability of Older Adults
Sponsor:
University of Virginia
Organization:
University of Virginia
Study Overview
Official Title:
Effects of an Oral GH Secretagogue MK-677 on Body Composition and Functional Ability of Older Adults
Status:
COMPLETED
Status Verified Date:
2007-05
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
MOT089
Brief Summary:
The purpose of this study is to determine whether treatment of healthy older men and women with oral MK-677 for 12 months will enhance pulsatile GH release and increase mean GH and IGF-I concentrations into the range of young adults and will have favorable effects on body composition and functional ability on older adults
Detailed Description:
This is a two year double-blind placebo-controlled cross-over trial of once daily administration of MK-677 an oral GH secretagogue to healthy older adults During the first year subjects will be randomized to MK-677 or placebo treatment In each of three subgroups of subjects men women off and women on hormone replacement therapy 16 subjects will receive MK-677 and 8 will receive placebo After 1 year the subjects who received placebo will be switched to MK-677 treatment the subjects who received MK-677 for the first year will be randomized to either placebo or MK-677 for the second year of the studyThe study will test changes in GH IGF-I body composition and function
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| NIH RO1 DK32632 | None | None | None |