Ignite Creation Date:
2024-05-05 @ 5:32 PM
Last Modification Date:
2024-10-26 @ 9:33 AM
Study NCT ID:
NCT00474500
Status:
COMPLETED
Last Update Posted:
2011-03-17
First Post:
2007-05-16
Brief Title:
Effect of Coca-Cola on Iron Absorption
Sponsor:
Quadram Institute Bioscience
Organization:
Quadram Institute Bioscience
Study Overview
Official Title:
Effect of Coca-Cola on Iron Absorption
Status:
COMPLETED
Status Verified Date:
2011-03
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The aim of this project is to measure the effect of Coca-Cola and Diet Coke relative to mineral water on non-haem iron absorption The results from this study will quantify any enhancing effect of Coca-Cola or Diet Coke on non-haem iron absorption and will be of use to the Coca-Cola Company and the scientific and nutrition community in evaluating the nutritional value of these products
Detailed Description:
Previous studies have suggested that Coca-Cola may enhance absorption of non-haem iron A randomized cross-over trial will be undertaken to compare the absorption of iron added to a pizza meal consumed with either Coca-Cola Diet Coke or mineral water Pizza containing added iron labelled with an iron stable isotope Fe-58 will be consumed for lunch on two consecutive days with either a Coca-Cola Diet Coke or mineral water drink Iron absorption from the pizza will be determined using the erythrocyte incorporation technique
A baseline blood sample will be taken prior to consuming the first test meal pizza drink 1 and after approximately 15 days a second fasting blood sample will be taken prior to consumption of a second set of test meals pizza drink 2 Iron isotope enrichment of the blood sample will be used as a baseline for the second set of test meals and to calculate absorption from the first set of test meals A third blood sample will be taken after approximately 30 days and the iron isotope enrichment will be used as a baseline for the third set of test meals pizza drink 3 and to determine absorption from the second set of test meals At about 45 days a final blood sample will be taken to determine absorption from the third set of test meals Iron absorption will be calculated from the isotopic enrichment in blood assuming that 80 of absorbed iron is incorporated into red blood cells Absorption of iron consumed with Coca-Cola and Diet Coke will be compared with iron absorption when consumed with mineral water The order in which the volunteers will be given the drinks will be randomised
A baseline blood sample will be taken prior to consuming the first test meal pizza drink 1 and after approximately 15 days a second fasting blood sample will be taken prior to consumption of a second set of test meals pizza drink 2 Iron isotope enrichment of the blood sample will be used as a baseline for the second set of test meals and to calculate absorption from the first set of test meals A third blood sample will be taken after approximately 30 days and the iron isotope enrichment will be used as a baseline for the third set of test meals pizza drink 3 and to determine absorption from the second set of test meals At about 45 days a final blood sample will be taken to determine absorption from the third set of test meals Iron absorption will be calculated from the isotopic enrichment in blood assuming that 80 of absorbed iron is incorporated into red blood cells Absorption of iron consumed with Coca-Cola and Diet Coke will be compared with iron absorption when consumed with mineral water The order in which the volunteers will be given the drinks will be randomised
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None