Ignite Creation Date:
2024-05-06 @ 5:07 PM
Last Modification Date:
2024-10-26 @ 2:23 PM
Study NCT ID:
NCT05206292
Status:
RECRUITING
Last Update Posted:
2024-06-03
First Post:
2022-01-06
Brief Title:
Estimating Prevalence of Inherited Disorders of Sulfur Amino Acids Metabolism in Patients With Psychotic Disorders
Sponsor:
University Hospital Grenoble
Organization:
University Hospital Grenoble
Study Overview
Official Title:
Estimating Prevalence of Inherited Disorders of Sulfur Amino Acids Metabolism in Patients With Psychotic Disorders
Status:
RECRUITING
Status Verified Date:
2024-05
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
PsyNIT
Brief Summary:
Screening for sulfur amino acid metabolism pathologies using a sulfitest in adult patients with psychotic disorder
Detailed Description:
Psychotic disorder is a public health problem with a cumulative incidence in the general population estimated at 3 Although in most cases the origin is purely psychiatric psychotic disorder can also represent a mode of entry into many organic pathologies Among these hereditary metabolic diseases although rare in the general population hold a special place especially in view of their potentially treatable character However the identification of this type of disease within the mass of patients with psychotic disorders can be an extremely complex task and has been the subject of scientific interest for many years
Recently at the Grenoble Alpes University Hospital a new hereditary metabolic disease that causes psychotic disorders has been discovered This disease was identified in a family of patients most of whom had psychotic disorders and all of whom had deep cystic leukoencephalopathy on MRI and a positive sulfitest The discovery of this new hereditary metabolic disease raises the question of its prevalence in patients with psychotic disorders and more generally of the prevalence of diseases of sulfur amino acid metabolism
PsyNIT study therefore aims using the sulfitest to detect hereditary diseases of sulfur amino acid metabolism in a sample of patients with psychotic disorders without known organic etiology The discovery of other patients would raise the question of screening more widely for this type of pathology and would modify the management of the patients thus screened in terms of follow-up and possibly treatment
Recently at the Grenoble Alpes University Hospital a new hereditary metabolic disease that causes psychotic disorders has been discovered This disease was identified in a family of patients most of whom had psychotic disorders and all of whom had deep cystic leukoencephalopathy on MRI and a positive sulfitest The discovery of this new hereditary metabolic disease raises the question of its prevalence in patients with psychotic disorders and more generally of the prevalence of diseases of sulfur amino acid metabolism
PsyNIT study therefore aims using the sulfitest to detect hereditary diseases of sulfur amino acid metabolism in a sample of patients with psychotic disorders without known organic etiology The discovery of other patients would raise the question of screening more widely for this type of pathology and would modify the management of the patients thus screened in terms of follow-up and possibly treatment
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 2021-A01940-41 | OTHER | ID RCB | None |