Ignite Creation Date:
2024-05-06 @ 5:07 PM
Last Modification Date:
2024-10-26 @ 2:22 PM
Study NCT ID:
NCT05204381
Status:
RECRUITING
Last Update Posted:
2024-01-10
First Post:
2022-01-11
Brief Title:
Theta Connectivity in Working Memory
Sponsor:
University of North Carolina Chapel Hill
Organization:
University of North Carolina Chapel Hill
Study Overview
Official Title:
Causal Role of Theta Connectivity in the Control of Working Memory
Status:
RECRUITING
Status Verified Date:
2024-01
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
STAR
Brief Summary:
The participants will perform a cognitive control task During the task rhythmic trains of transcranial magnetic stimulation will be delivered to the prefrontal cortex and parietal cortex Participants will be screened for their ability to perform the task Magnetic resonance imaging will be used to localize regions of interest to be targeted Electroencephalography will be collected concurrent with stimulation
Detailed Description:
This study is a pilot five-session study with transcranial magnetic stimulation TMS electroencephalography EEG and magnetic resonance imaging MRI to understand the neural oscillatory basis of output-gating The first session of the experiment will be screening session in which participants provide written consent to participate screened for colorblindness complete questionnaires and perform a working memory task with retrospective cues Participants will be invited back to the second session if they show a benefit to their working memory percent correct by use of the informative retro-cue relative to the uninformative neutral cue This session will also be used to select the number of items that will be used in the working memory task for subsequent sessions The criteria for difficulty titration is task performance between 60 and 85 correct for retro-cue trials and a benefit of at least 5 greater than neutral cue trials Thus different participants will perform the task with different numbers of items to be encoded into working memory Titration of task difficulty as described here is critical for experiments that use causal manipulation eg transcranial magnetic stimulation to modulate performance If participants are performing at ceiling close to 100 or at floor close to random change then any experimental manipulation of behavior is less likely to impact performance as the task is too easy or too hard For the second session of the experiment participants perform the working memory retro-cue task while EEG is recorded In addition participants will complete a simple perception color task in which participants see a color and choose the matching color from the color circle This task tests for the precision of perception throughout the color circle The EEG data from the second session will be preprocessed and a Morlet wavelet convolution analysis will be conducted The resulting spectrogram will be contrasted between the informative retro-cue and uninformative neutral cue to derive the theta frequency with peak amplitude in prefrontal cortex and contrasted between a leftward and rightward retro-cue to derive the alpha frequency with peak amplitude in parietal cortex These peak frequencies will be used for stimulation in the fourth and fifth session In the third session the investigators will acquire structural and functional MRI for each participant The functional MRI data will be analyzed to identify regions in the anterior middle frontal gyrus and posterior intraparietal sulcus that are functionally connected within the frontal-parietal executive control network A previous meta-analysis of functional MRI studies found that the regions with peak retro-cue activity was at Montreal Neurological Institute coordinates -40 36 28 for anterior middle frontal gyrus and -38 -48 44 for inferior intraparietal sulcus Therefore the investigators will constrain the search light to the anatomical landmarks and these coordinates The center of mass in these regions will be used for targeting with TMS in the subsequent fourth and fifth sessions In the fourth and fifth sessions stimulation will be delivered at the timing relative to retro-cue frequency and spatial location based on previous localizers During stimulation the location of the TMS coil needs to be aligned to the targeted brain region with neuro-navigation software that records the accuracy of each TMS pulse relative to the target On each trial the stimulation type will be randomly selected counter-balanced and inter-mixed The effects of rhythmic TMS are not expected to last for more than a few cycles beyond stimulation itself Therefore the experimental design randomly intermixes the stimulation type within every task block
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
True
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
True
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 1R01MH124387 | NIH | None | httpsreporternihgovquickSearch1R01MH124387 |