Ignite Creation Date:
2024-05-05 @ 5:32 PM
Last Modification Date:
2024-10-26 @ 9:33 AM
Study NCT ID:
NCT00477074
Status:
COMPLETED
Last Update Posted:
2007-05-22
First Post:
2007-05-18
Brief Title:
Pulmonary and Systemic Hepatocyte Growth Factors in Patients With COPD
Sponsor:
Hospital Universitari Son Dureta
Organization:
Hospital Universitari Son Dureta
Study Overview
Official Title:
Pulmonary and Systemic Hepatocyte Anb Keratinocyte Growth Factors in Patients With Chronic Obstructive Pulmonary Disease
Status:
COMPLETED
Status Verified Date:
2007-05
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The role of HGF and KGF in COPD is poorly known Plantier et al found that cultured fibroblasts harvested from patients with emphysema produced less HGF but similar amounts of KGF than controls and Bonay et al found a direct relationship between the severity of airflow obstruction and HGF mRNA content in lung samples of smokers These two studies suggest therefore that the pulmonary regulation of HGF may be abnormal in patients with COPD However both HGF and KGF can also be released by extra-pulmonary organs thus having the potential to act systemically Given the current clinical relevance attributed to the systemic effects of COPD in this study we compared the levels of HGF and KGF in the pulmonary bronchoalveolar lavage BAL fluid and systemic compartment circulating blood of smokers with and without COPD and never smokers
Detailed Description:
Background The potential role of growth factors in COPD has begun to be addressed only recently and is still poorly understood In this study we investigate potential abnormalities of hepatocyte growth factor HGF and keratinocyte growth factor KGF in patients with COPD
Methods To this end we compared the levels of HGF and KGF measured by ELISA in bronchoalveolar lavage BAL fluid and in serum in 18 patients with COPD 62 2 yrs FEV1 57 4 ref X SEM 18 smokers with normal lung function 58 2 yrs FEV1 90 4 ref and 8 never smokers 67 7 yrs 94 4 ref
Results We found that in BAL HGF levels were higher in patients with COPD than in the other two groups whereas in serum HGF concentration was highest in smokers with normal lung function p001 KGF levels were not significantly different between groups neither in blood nor in BAL most values were below the detection limit
Conclusions These results highlight a different response of HGF in BAL and serum in smokers with and without COPD that may be relevant for tissue repair in COPD
Methods To this end we compared the levels of HGF and KGF measured by ELISA in bronchoalveolar lavage BAL fluid and in serum in 18 patients with COPD 62 2 yrs FEV1 57 4 ref X SEM 18 smokers with normal lung function 58 2 yrs FEV1 90 4 ref and 8 never smokers 67 7 yrs 94 4 ref
Results We found that in BAL HGF levels were higher in patients with COPD than in the other two groups whereas in serum HGF concentration was highest in smokers with normal lung function p001 KGF levels were not significantly different between groups neither in blood nor in BAL most values were below the detection limit
Conclusions These results highlight a different response of HGF in BAL and serum in smokers with and without COPD that may be relevant for tissue repair in COPD
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None