Ignite Creation Date:
2024-05-05 @ 5:32 PM
Last Modification Date:
2024-10-26 @ 9:33 AM
Study NCT ID:
NCT00477737
Status:
COMPLETED
Last Update Posted:
2007-05-24
First Post:
2007-05-22
Brief Title:
Early Cardioprotective Effect of Sevoflurane
Sponsor:
University Hospital Dubrava
Organization:
University Hospital Dubrava
Study Overview
Official Title:
Early Cardioprotective Effect of Sevoflurane on Left Ventricular Performance During Coronary Artery Bypass Grafting on a Beating Heart
Status:
COMPLETED
Status Verified Date:
2007-05
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
In vitro studies and in vivo animal experiments have shown that halogenated volatile anesthetics have a protective effect on the ischemic myocardium In clinical settings however anesthetic preconditioning may be of more interest The aim of our study was to evaluate the cardioprotective effect of sevoflurane in patients undergoing off-pump coronary artery bypass surgery We proposed that a cardioprotective effect of sevoflurane would save myocardial function which we measured acceleration by esophageal Doppler and cardiac index with bolus thermodilution methods both during brief ischemia and reperfusion
Detailed Description:
Studies have been performed on human patients undergoing CABG surgery with cardiopulmonary bypass CPB Only a few studies however have evaluated the effects of volatile anesthetics during coronary artery bypass grafting on a beating heart OPCABG with conflicting results as far as cardiac biomarker release is concerned
Because CPB is known to have a profound impact on cardiac function studies performed on patients scheduled for OPCABG could evaluate more specifically the effects of the anesthetic agents themselves Patients undergoing OPCABG have a predictable and predefined ischemic zone during surgery and represent an extremely interesting and safe model for the study of ischemia and cardiac damage in humans
Presently there is still no consensus on the method of administration of volatile anesthetics including the time to begin administration its duration the dosage and selection of volatile anesthetics
Because CPB is known to have a profound impact on cardiac function studies performed on patients scheduled for OPCABG could evaluate more specifically the effects of the anesthetic agents themselves Patients undergoing OPCABG have a predictable and predefined ischemic zone during surgery and represent an extremely interesting and safe model for the study of ischemia and cardiac damage in humans
Presently there is still no consensus on the method of administration of volatile anesthetics including the time to begin administration its duration the dosage and selection of volatile anesthetics
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None