Ignite Creation Date:
2024-05-05 @ 5:32 PM
Last Modification Date:
2024-10-26 @ 9:32 AM
Study NCT ID:
NCT00471731
Status:
COMPLETED
Last Update Posted:
2018-02-14
First Post:
2007-05-09
Brief Title:
Dry Eye in Women With Turner Syndrome and Women With Premature Ovarian Failure
Sponsor:
National Eye Institute NEI
Organization:
National Institutes of Health Clinical Center CC
Study Overview
Official Title:
Ocular Impact of X Chromosome Karyotype and Sex Hormones in Turner Syndrome
Status:
COMPLETED
Status Verified Date:
2014-11-13
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Premature ovarian failure POF is known to be associated with an increased risk of ocular surface disease dry eye likely due to the reduction of both estrogens and androgens seen in this condition From preliminary data we suspect that women with Turners syndrome 45 XO a genetic abnormality that affects sex hormone levels are also at increased risk of ocular surface disease Comparing POF and TS women may allow us to distinguish different mechanisms for ocular surface disease due to the different etiologies of hormonal estrogen and androgen alterations posed by POF and TS
Detailed Description:
Premature ovarian failure POF is known to be associated with an increased risk of ocular surface disease dry eye likely due to the reduction of both estrogens and androgens seen in this condition From preliminary data we suspect that women with Turners syndrome 45 XO a genetic abnormality that affects sex hormone levels are also at increased risk of ocular surface disease Comparing POF and TS women may allow us to distinguish different mechanisms for ocular surface disease due to the different etiologies of hormonal estrogen and androgen alterations posed by POF and TS
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 07-EI-0145 | None | None | None |