Ignite Creation Date:
2024-05-06 @ 5:04 PM
Last Modification Date:
2024-10-26 @ 2:22 PM
Study NCT ID:
NCT05188131
Status:
COMPLETED
Last Update Posted:
2022-01-12
First Post:
2021-12-01
Brief Title:
Acute Neuroendocrine Response to Intravenous Infusion of Diclofenac Sodium
Sponsor:
Azienda Ospedaliera Città della Salute e della Scienza di Torino
Organization:
Azienda Ospedaliera Città della Salute e della Scienza di Torino
Study Overview
Official Title:
Acute Neuroendocrine Response to Intravenous Infusion of Diclofenac Sodium
Status:
COMPLETED
Status Verified Date:
2022-01
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The effects of acute administration of non-steroidal anti-inflammatory drugs NSAIDs on the neuroendocrine regulation of hydro-electrolytic metabolism are not precisely known to date
Although the mechanism by which NSAIDs favor the antidiuretic action of vasopressin AVP in the kidney has been partially elucidated their influence on the mechanisms responsible for regulating its secretion are less known The interactions between NSAIDs and natriuretic peptides are also not entirely certain
The present pharmacological research study therefore aims to investigate in a cohort of healthy subjects the acute effects of intravenous infusion of diclofenac sodium on the neuroendocrine regulation systems of water and salt balance ie the antidiuretic axis and the system of natriuretic peptides
Although the mechanism by which NSAIDs favor the antidiuretic action of vasopressin AVP in the kidney has been partially elucidated their influence on the mechanisms responsible for regulating its secretion are less known The interactions between NSAIDs and natriuretic peptides are also not entirely certain
The present pharmacological research study therefore aims to investigate in a cohort of healthy subjects the acute effects of intravenous infusion of diclofenac sodium on the neuroendocrine regulation systems of water and salt balance ie the antidiuretic axis and the system of natriuretic peptides
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None