Ignite Creation Date:
2024-05-06 @ 5:01 PM
Last Modification Date:
2024-10-26 @ 2:20 PM
Study NCT ID:
NCT05167942
Status:
UNKNOWN
Last Update Posted:
2021-12-22
First Post:
2021-12-10
Brief Title:
Exploration of the Deep Transcranial Magnetic Stimulation for Treatment Resistant Schizophrenia
Sponsor:
Shanghai Mental Health Center
Organization:
Shanghai Mental Health Center
Study Overview
Official Title:
Exploration of the Deep Transcranial Magnetic Stimulation for Treatment Resistant Schizophrenia
Status:
UNKNOWN
Status Verified Date:
2021-11
Last Known Status:
RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Negative symptoms and cognitive dysfunction are of importance for the prognosis of the patients of schizophrenia Based on the hypothesis that deep transcranial magnetic stimulationdTMS on prefrontal cortex PFC could down-regulate the glutamate level of PFC and regulate the functional network in patients with treatment resistance schizophreniathis research plan to utilise multimodal functional magnetic imaging methodincluding structural MRIresting-state functional magnetic resonance imaging and 1H-MRS to investigate therapeutic efficacy of high-frequency deep transcranial magnetic stimulation on SZ patients symptomsas well as to elucidate the correlation between treatment effects and glutamate level of PFC
Detailed Description:
This study includes 87 treatment resistance schizophrenia patients This study will investigate 1abnormalities of the glutamate level of PFC in patients with schizophrenia compared to healthy controls by using 1H-MRS technique 2potential modulation effects of deep transcranial magnetic stimulationdTMS on prefrontal cortex function of patients with schizophrenia 3the therapeutic efficacy of dTMS on cognitive impairments and other psychotic symptoms of patients with schizophrenia by adopting cognitive function and psychotic symptoms evaluationas well as to explore the optimal dTMS treatment pattern on cognitive function
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
False
Is an FDA AA801 Violation?:
None