Ignite Creation Date:
2024-05-05 @ 5:31 PM
Last Modification Date:
2024-10-26 @ 9:32 AM
Study NCT ID:
NCT00470106
Status:
COMPLETED
Last Update Posted:
2016-04-22
First Post:
2007-05-04
Brief Title:
Improving Basic and Social Cognition in Veterans With Schizophrenia
Sponsor:
VA Office of Research and Development
Organization:
VA Office of Research and Development
Study Overview
Official Title:
Improving Basic and Social Cognition in Veterans With Schizophrenia
Status:
COMPLETED
Status Verified Date:
2016-03
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
IBASC
Brief Summary:
Veterans with schizophrenia and schizoaffective disorder experience very high levels of disability and poor community outcome Further improvements in community outcome for patients with these disorders will not occur simply through better control of clinical symptoms Instead it will be necessary to find treatments that address the key determinants of poor functional outcome Evidence strongly suggests that basic non-social cognitive and social cognitive deficits are among the key determinants of functional outcome for these illnesses The primary goal of this 2-year pilot study is to implement and validate a new remediation program for social cognition that is appropriate for veterans with schizophrenia and schizoaffective disorder
Detailed Description:
Veterans with schizophrenia and schizoaffective disorder experience very high levels of disability and poor community outcome Further improvements in community outcome for patients with these disorders will not occur simply through better control of clinical symptoms Instead it will be necessary to find treatments that address the key determinants of poor functional outcome Evidence strongly suggests that basic non-social cognitive and social cognitive deficits are among the key determinants of functional outcome for these illnesses The primary goal of this 2-year pilot study is to implement and validate a new remediation program for social cognition that is appropriate for veterans with schizophrenia and schizoaffective disorder
We plan to recruit 72 patients over the 2 years of the study from the outpatient clinics at the VA Greater Los Angeles Healthcare System VAGLAHS They will receive baseline assessment that includes measures of social cognition basic cognition electrophysiology functional capacity clinical symptoms community status and demographics clinical history Follow up assessments will be administered at the mid-point of training at 6 weeks and end of training at 12 weeks Each follow up assessment will include measures of basic cognition social cognition electrophysiology functional capacity and clinical symptoms The tester administering the assessments will be blind to treatment group
Subjects will be randomly assigned to one of four groups 1 social cognitive training 2 basic cognitive remediation 3 a combined social cognitive and basic cognitive intervention or 4 social skills training All groups will meet in one-hour sessions held twice a week over the course of 12 weeks in small groups of 3-6 The Social Cognition Intervention SCI is a new 24-session manualized intervention program specifically designed to improve emotion perception social context processing and theory of mind attributional bias in veterans with schizophrenia and schizoaffective disorder The Basic Cognitive Intervention BCI will involve computer-assisted training exercises Each participant will work individually on a notebook computer The combined intervention will cover the same content areas as the social cognitive and basic cognitive interventions but will not go into as much detail as the separate intervention programs The control condition will be facilitated discussion of current events Treatment will be administered in a group format with three to six patients and a training coach
We plan to recruit 72 patients over the 2 years of the study from the outpatient clinics at the VA Greater Los Angeles Healthcare System VAGLAHS They will receive baseline assessment that includes measures of social cognition basic cognition electrophysiology functional capacity clinical symptoms community status and demographics clinical history Follow up assessments will be administered at the mid-point of training at 6 weeks and end of training at 12 weeks Each follow up assessment will include measures of basic cognition social cognition electrophysiology functional capacity and clinical symptoms The tester administering the assessments will be blind to treatment group
Subjects will be randomly assigned to one of four groups 1 social cognitive training 2 basic cognitive remediation 3 a combined social cognitive and basic cognitive intervention or 4 social skills training All groups will meet in one-hour sessions held twice a week over the course of 12 weeks in small groups of 3-6 The Social Cognition Intervention SCI is a new 24-session manualized intervention program specifically designed to improve emotion perception social context processing and theory of mind attributional bias in veterans with schizophrenia and schizoaffective disorder The Basic Cognitive Intervention BCI will involve computer-assisted training exercises Each participant will work individually on a notebook computer The combined intervention will cover the same content areas as the social cognitive and basic cognitive interventions but will not go into as much detail as the separate intervention programs The control condition will be facilitated discussion of current events Treatment will be administered in a group format with three to six patients and a training coach
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None