Ignite Creation Date:
2024-05-06 @ 5:00 PM
Last Modification Date:
2024-10-26 @ 2:20 PM
Study NCT ID:
NCT05161104
Status:
ENROLLING_BY_INVITATION
Last Update Posted:
2021-12-16
First Post:
2021-11-23
Brief Title:
A Multicenter Cross-sectional Study of Cardiac Ultrasound Phenotypes in Patients With Sepsis
Sponsor:
Fujian Provincial Hospital
Organization:
Fujian Provincial Hospital
Study Overview
Official Title:
A Multicenter Cross-sectional Study of Cardiac Ultrasound Phenotypes in Patients With Sepsis
Status:
ENROLLING_BY_INVITATION
Status Verified Date:
2021-11
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The heart one of the most important organs for oxygen supply and consumption is frequently involved in sepsis ie septic cardiomyopathy also known as septic myocardial suppression The occurrence of septic myocardial suppression increases mortality in septic patients Recent studies have found that left ventricular hyperdynamic state EF 70 is associated with intra-ICU mortality in septic patients possibly because it reflects unresolved vascular paralysis from sepsis For septic myocardial suppression there is still a lack of uniform criteria for diagnosis but it is well established that the cardiac ultrasound phenotype of septic myocardial suppression can be left ventricular systolic insufficiency LVSD left ventricular diastolic insufficiency LVDD right ventricular insufficiency RVD diffuse ventricular insufficiency and mixed ventricular insufficiency According to incomplete statistics the prevalence of LVSD ranges from 12 to 60 the prevalence of LVDD is higher 20 to 79 and the prevalence of RVD varies from 30 to 55 However based on the current understanding of septic myocardial suppression the relationship between each staging and its prognosis is unclear and echocardiography can rapidly identify septic myocardial suppression and guide the classification of septic myocardial suppression to further optimize the diagnosis and treatment process of sepsis especially to avoid over-resuscitation during fluid resuscitation and perform reverse resuscitation in a timely manner to improve patient prognosis and reduce hospitalization time The aim of this study is to classify and evaluate the prognosis of patients with different septic cardiac ultrasound phenotypes in multiple centers across China by measuring the right and left heart systolic and diastolic indices by echocardiography recording the baseline conditions and clinical indices of patients and combining them with the prognosis
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None