Ignite Creation Date:
2024-05-05 @ 5:31 PM
Last Modification Date:
2024-10-26 @ 9:32 AM
Study NCT ID:
NCT00472875
Status:
UNKNOWN
Last Update Posted:
2007-05-14
First Post:
2007-05-10
Brief Title:
Do Sulphonylureas Preserve Cortical Function During Hypoglycaemia
Sponsor:
Kings College Hospital NHS Trust
Organization:
Kings College Hospital NHS Trust
Study Overview
Official Title:
None
Status:
UNKNOWN
Status Verified Date:
2007-05
Last Known Status:
RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
To see if using medication called sulphonylureas can help improve symptoms which patients rely on to recognise low blood glucose levels hypoglycaemia and also to see if they can reduce the slowing down in brain function which occurs at hypoglycaemia
Detailed Description:
Low blood glucose hypoglycaemia is the most common and important side effect of insulin treatment for diabetes Most episodes are mild and lead to symptoms that alert the individual to raise their blood sugar level by consuming sugar or starch carbohydrate The body also responds to low blood sugars by producing hormones such as adrenaline and cortisol which help to restore blood sugar levels to normal As the brain relies on sugar for fuel it does not function properly if blood sugar levels drop too low resulting in confusion and in extreme cases reduced conscious levels
Repeated hypoglycaemia can blunt the protective symptoms and hormonal responses to hypoglycaemia limiting patients ability to recognise and correct hypoglycaemia putting them at high risk of even more hypoglycaemia Heller and Cryer 1991
Sulphonylureas are tablets used to treat type 2 diabetes that work by stimulating the pancreas to make more insulin They do this by closing pores called KATP channels which are found on the surface of many cells and control the rate of firing of cells In the pancreas closing them causes cells to fire and release insulin However in other tissues such as in the brain these channels have a protective function and they open up during times of lack of fuel such as lack of oxygen or sugar preventing the cells from firing and putting them into a resting mode which reduces their energy requirementDunn-Meynell Rawson and Levin 1998 However if the brain cells responsible for generating symptoms are put into this resting mode they may not produce symptoms which may contribute to hypoglycaemia unawareness
Repeated hypoglycaemia can blunt the protective symptoms and hormonal responses to hypoglycaemia limiting patients ability to recognise and correct hypoglycaemia putting them at high risk of even more hypoglycaemia Heller and Cryer 1991
Sulphonylureas are tablets used to treat type 2 diabetes that work by stimulating the pancreas to make more insulin They do this by closing pores called KATP channels which are found on the surface of many cells and control the rate of firing of cells In the pancreas closing them causes cells to fire and release insulin However in other tissues such as in the brain these channels have a protective function and they open up during times of lack of fuel such as lack of oxygen or sugar preventing the cells from firing and putting them into a resting mode which reduces their energy requirementDunn-Meynell Rawson and Levin 1998 However if the brain cells responsible for generating symptoms are put into this resting mode they may not produce symptoms which may contribute to hypoglycaemia unawareness
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| JDRF grant number 5-2007-478 | None | None | None |