Ignite Creation Date:
2024-05-06 @ 4:55 PM
Last Modification Date:
2024-10-26 @ 2:19 PM
Study NCT ID:
NCT05139862
Status:
NOT_YET_RECRUITING
Last Update Posted:
2022-02-02
First Post:
2021-11-17
Brief Title:
Neurocardiac Predictors of Treatment Response to rTMS in Depression
Sponsor:
University of British Columbia
Organization:
University of British Columbia
Study Overview
Official Title:
Neuro-cardiac Predictors of Treatment Response to rTMS in Depression A Mechanistic Study Using Interleaved TMS-fMRI
Status:
NOT_YET_RECRUITING
Status Verified Date:
2022-01
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
NCP
Brief Summary:
Heartbeat is controlled by the brain and is regular but flexible to change in response to environmental and internal stimuli This feature is known as heart rate variability HRV Major depressive disorder MDD has been associated with diminished HRV and this is a reflection of abnormal brain function caused by MDD Repetitive transcranial magnetic stimulation rTMS is a treatment that stimulates specific areas of the brain The goal of this study is to test the hypothesis that rTMS induces changes in connectivity between the area of the brain stimulated with rTMS and deeper areas in the brain associated to heart rate regulation 110 patients with TRD will be recruited and will undergo a concurrent TMS-fMRI session before receiving a course of iTBS to the L-DLPFC for 30 sessions at 120 rMT
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None