Ignite Creation Date:
2024-05-05 @ 5:30 PM
Last Modification Date:
2024-10-26 @ 9:32 AM
Study NCT ID:
NCT00464035
Status:
COMPLETED
Last Update Posted:
2009-01-21
First Post:
2007-04-19
Brief Title:
The Effect of Calcium on Postprandial Lipid Profile and Appetite
Sponsor:
University of Copenhagen
Organization:
University of Copenhagen
Study Overview
Official Title:
None
Status:
COMPLETED
Status Verified Date:
2004-12
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The purpose of this study is to investigate the effect of calcium on postprandial lipid profile and appetite
Detailed Description:
Several reports have found inverse associations between calcium intake and body weight Intervention studies have shown that a high calcium diet resulted in a greater body weight loss than a low calcium diet In addition it seems that calcium from dairy products have a more profound effect than calcium from supplements The mechanism of this additional dairy effect is not yet clear but one possible explanation could be reduced absorption of fat in the gut The increase in fecal fat excretion on a high calcium diet could be due to the formation of calcium-fatty acid soaps in the gut
The long term effect of a high calcium intake have been under intense investigation but as far as we know the acute effect of a high calcium intake have not yet been examined A study concerning the acute effects could help us understand the effect of calcium on the absorption of fat After a meal triglyceride TG is packaged with cholesterol lipoproteins and other lipids into particles called chylomicrons Earlier studies have shown that the fatty acid pattern of chylomicron lipids postprandial was very similar to that of the ingested fat If we assume that calcium inhibits the absorption of fat we would expect a reduced total plasma triglyceride concentration after a calcium-rich meal
Appetite involves many different sensations among which hunger and satiety are the most investigated Several different hormones are involved in the regulation of appetite Some of these hormones are known to respond to the intake or absorption of fat If the absorption of fat is inhibited the regulation of appetite most likely will be affected In the long term this could be important because an increased appetite probably would increase energy intake and thereby reducing the weight loss we otherwise might have accomplished by the reduced absorption of fat
The long term effect of a high calcium intake have been under intense investigation but as far as we know the acute effect of a high calcium intake have not yet been examined A study concerning the acute effects could help us understand the effect of calcium on the absorption of fat After a meal triglyceride TG is packaged with cholesterol lipoproteins and other lipids into particles called chylomicrons Earlier studies have shown that the fatty acid pattern of chylomicron lipids postprandial was very similar to that of the ingested fat If we assume that calcium inhibits the absorption of fat we would expect a reduced total plasma triglyceride concentration after a calcium-rich meal
Appetite involves many different sensations among which hunger and satiety are the most investigated Several different hormones are involved in the regulation of appetite Some of these hormones are known to respond to the intake or absorption of fat If the absorption of fat is inhibited the regulation of appetite most likely will be affected In the long term this could be important because an increased appetite probably would increase energy intake and thereby reducing the weight loss we otherwise might have accomplished by the reduced absorption of fat
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None