Ignite Creation Date:
2024-05-05 @ 5:30 PM
Last Modification Date:
2024-10-26 @ 9:32 AM
Study NCT ID:
NCT00467623
Status:
COMPLETED
Last Update Posted:
2008-10-17
First Post:
2007-04-27
Brief Title:
Holotranscobalamin Remains Unchanged During Pregnancy
Sponsor:
University of Aarhus
Organization:
University of Aarhus
Study Overview
Official Title:
Holotranscobalamin Remains Unchanged During Pregnancy Longitudinal Changes of Cobalamins and Its Binding Proteins During Pregnancy and Postpartum
Status:
COMPLETED
Status Verified Date:
2007-04
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Background and objective Plasma cobalamins decrease during pregnancy but it is not fully elucidated how this is reflected in the total and cobalamin saturated transport proteins transcobalamin total TC holoTC and haptocorrin total HC holoHC TC transports cobalamin into the cells The function of HC is unknown but in contrast to TC it binds both cobalamins and cobalamin analogues
Design and methods Healthy pregnant women N141 had blood samples drawn at 18th 32nd 39th gestation week and 8 weeks postpartum The protein moiety of TC and HC total and holo was measured by in-house ELISA methods
Design and methods Healthy pregnant women N141 had blood samples drawn at 18th 32nd 39th gestation week and 8 weeks postpartum The protein moiety of TC and HC total and holo was measured by in-house ELISA methods
Detailed Description:
Background and objective Plasma cobalamins decrease during pregnancy but it is not fully elucidated how this is reflected in the total and cobalamin saturated transport proteins transcobalamin total TC holoTC and haptocorrin total HC holoHC TC transports cobalamin into the cells The function of HC is unknown but in contrast to TC it binds both cobalamins and cobalamin analogues
Design and methods Healthy pregnant women N141 had blood samples drawn at 18th 32nd 39th gestation week and 8 weeks postpartum The protein moiety of TC and HC total and holo was measured by in-house ELISA methods
Design and methods Healthy pregnant women N141 had blood samples drawn at 18th 32nd 39th gestation week and 8 weeks postpartum The protein moiety of TC and HC total and holo was measured by in-house ELISA methods
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None