Ignite Creation Date:
2024-05-05 @ 5:30 PM
Last Modification Date:
2024-10-26 @ 9:32 AM
Study NCT ID:
NCT00467389
Status:
COMPLETED
Last Update Posted:
2014-06-09
First Post:
2007-04-27
Brief Title:
Use of Donepezil for Treatment of Cocaine Dependence
Sponsor:
US Department of Veterans Affairs
Organization:
VA Office of Research and Development
Study Overview
Official Title:
Donepezil Effects on Cocaine Craving and Pharmacokinetics
Status:
COMPLETED
Status Verified Date:
2014-05
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The purpose of this study is to determine the safety of intravenous cocaine in subjects receiving oral donepezil
Detailed Description:
This is a randomized double-blind double-dummy placebo controlled inpatient single-center parallel group evaluation of the potential for oral donepezil to attenuate cocaine-induced craving Non-treatment-seeking cocaine-experienced volunteers will receive baseline treatment with intravenous cocaine 30Mg Forty-two subjects that tolerate baseline cocaine infusions will then receive two subsequent intravenous doses of cocaine during double-blind treatment with oral placebo or 5 mg daily of donepezil Each dose of cocaine will be preceded or followed by administration of intravenous placebo saline in a random order
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None