Ignite Creation Date:
2024-05-05 @ 5:30 PM
Last Modification Date:
2024-10-26 @ 9:32 AM
Study NCT ID:
NCT00463333
Status:
COMPLETED
Last Update Posted:
2007-04-20
First Post:
2005-09-10
Brief Title:
Postoperative Delirium at Heidelbergs Intensive Care Unit -New Diagnostic Markers
Sponsor:
Heidelberg University
Organization:
Heidelberg University
Study Overview
Official Title:
None
Status:
COMPLETED
Status Verified Date:
2007-04
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Summary
Postoperative delirium is a highly prevalent disease 10-30 prevalence after surgery in intensive care unit however it is often misdiagnosed and mistreated The aim of the present project is to investigate risk factors for postoperative delirium in more detail to evaluate respective cognitive test systems and to measure EEG activity parallel to patients serum anticholinergic activity The pathophysiology of delirium is unknown up to now a possible dysbalance between cerebral acetylcholine and dopamine concentrations is a likely hypothesis Therefore the measurement of peripheral serum anticholinergic activity could be a new prognostic factor for evaluation of delirium Because delirium is also associated with higher postoperative mortality and morbidity with delayed functional recovery and postoperative delirium makes patient management much more difficult increases costs and above all causes severe discomfort to the patient new interdisciplinary diagnostic strategies are necessary to resolve this problem
Postoperative delirium is a highly prevalent disease 10-30 prevalence after surgery in intensive care unit however it is often misdiagnosed and mistreated The aim of the present project is to investigate risk factors for postoperative delirium in more detail to evaluate respective cognitive test systems and to measure EEG activity parallel to patients serum anticholinergic activity The pathophysiology of delirium is unknown up to now a possible dysbalance between cerebral acetylcholine and dopamine concentrations is a likely hypothesis Therefore the measurement of peripheral serum anticholinergic activity could be a new prognostic factor for evaluation of delirium Because delirium is also associated with higher postoperative mortality and morbidity with delayed functional recovery and postoperative delirium makes patient management much more difficult increases costs and above all causes severe discomfort to the patient new interdisciplinary diagnostic strategies are necessary to resolve this problem
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None