Ignite Creation Date:
2024-05-05 @ 5:29 PM
Last Modification Date:
2024-10-26 @ 9:32 AM
Study NCT ID:
NCT00465140
Status:
COMPLETED
Last Update Posted:
2007-04-24
First Post:
2007-04-23
Brief Title:
Effects of Creatine Supplementation on Renal Function
Sponsor:
University of Sao Paulo
Organization:
University of Sao Paulo
Study Overview
Official Title:
Effects of Creatine Supplementation on Renal Function in Sedentary Healthy Males Urdergoing Aerobic Training a Randomized Double-Blind Placebo-Controlled Trial
Status:
COMPLETED
Status Verified Date:
2007-04
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Creatine CR supplementation is commonly used by athletes However its effects on renal function remain controversial The aim of this study was to evaluate the effects of creatine supplementation on renal function and oxidative stress in healthy sedentary males 18-35 years old submitted to exercise training Our hipothesis is that creatine supplementation does not affect renal function in this population
Detailed Description:
Creatine CR supplementation is commonly used by athletes However its effects on renal function remain controversial Purpose The aim of this study was to evaluate the effects of creatine supplementation on renal function and oxidative stress in healthy sedentary males 18-35 years old submitted to exercise training Methods Subjects n 18 were randomly divided in two groups and were allocated to receive treatment with either creatine CR 10g day-1 over three months or placebo PL dextrose All subjects undertook moderate intensity aerobic training in three 40-minute sessions per week during 3 months Serum creatinine TBARS serum and urinary sodium and potassium were determined at baseline and at the study endpoint Furthermore cystatin C was also assessed prior to training PRE after 4 POST 4 and 12 weeks POST 12 Results There were decreased in both oxidative stress evaluated by TBARS - µM24 h PRE CR 82 44 PL 64 08 vs POST 12 CR 25 18 PL 21 16 p00001 and cystatin C levels mgL PRE CR082 009 PL 088 007 vs POST 12 CR 071 006 PL 075 009 p00001 over the time suggesting an increase in glomerular filtration rate There were no significant differences between groups in other renal parameters investigated Conclusions These data indicate that high-dose creatine supplementation throughout three months does not provoke renal dysfunction in sedentary healthy males urdergoing aerobic training Moreover our results suggest that moderate aerobic training per se could improve renal function
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None