Ignite Creation Date:
2024-05-06 @ 4:50 PM
Last Modification Date:
2024-10-26 @ 2:17 PM
Study NCT ID:
NCT05105217
Status:
UNKNOWN
Last Update Posted:
2021-11-03
First Post:
2021-10-07
Brief Title:
Evaluation of Slit2 in Systemic Lupus Erythematosus and Systemic Sclerosis Patients
Sponsor:
Assiut University
Organization:
Assiut University
Study Overview
Official Title:
Evaluation of Slit2 in Systemic Lupus Erythematosus and Systemic Sclerosis Patients
Status:
UNKNOWN
Status Verified Date:
2021-10
Last Known Status:
NOT_YET_RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
1Assessment of slit2 level in SLE patients and its correlation with disease activity
2-Assessment of slit2 level in SSC patients and its correlation with disease activity
2-Assessment of slit2 level in SSC patients and its correlation with disease activity
Detailed Description:
Systemic lupus erythematosus SLE is the most serologically and clinically diverse autoimmune disease Immune dysregulation leads to excess production of autoantibodies and immune complexes excess complement activation and insidious tissue inflammation in patients with SLE
SLE is characterized by multisystem involvement commonly affecting the skin renal and musculoskeletal systems
Lupus nephritis is an important cause of both acute kidney injury and chronic kidney disease that can result in end-stage renal disease Its pathogenic mechanisms are characterized by aberrant activation of both innate and adaptive immune responses dysregulation of inflammatory signaling pathways and increased cytokines production
Systemic sclerosis SSC is an autoimmune disease with characteristic vascular damage and fibrosis of the skin and internal organs Diagnosis of SSC is mainly based on the clinical course and features in addition to laboratory findings including autoantibody profiles
Slit2 as a member of the Slit family is secreted glycoprotein Slit2 functions by binding to its transmembrane receptor Robo Robo has four isoforms Robo14 Slit2-Robo regulates cell functions such as regulating leukocytes in chemotaxis and promoting endothelial cell migration and tube formation
Slit2 might promote the pathogenesis of LN by affecting various cell dysfunction in addition to leukocyte infiltration
In SSC vascular involvement is a primary event characterized by vascular tone dysfunction and microcirculatory abnormalities Many classes of guidance molecules such as members of the secreted glycoproteins Slits and their Roundabout Robo receptors play critical roles in angiogenesis Among these Robo1 and Robo4 are expressed in endothelial cells
SLE is characterized by multisystem involvement commonly affecting the skin renal and musculoskeletal systems
Lupus nephritis is an important cause of both acute kidney injury and chronic kidney disease that can result in end-stage renal disease Its pathogenic mechanisms are characterized by aberrant activation of both innate and adaptive immune responses dysregulation of inflammatory signaling pathways and increased cytokines production
Systemic sclerosis SSC is an autoimmune disease with characteristic vascular damage and fibrosis of the skin and internal organs Diagnosis of SSC is mainly based on the clinical course and features in addition to laboratory findings including autoantibody profiles
Slit2 as a member of the Slit family is secreted glycoprotein Slit2 functions by binding to its transmembrane receptor Robo Robo has four isoforms Robo14 Slit2-Robo regulates cell functions such as regulating leukocytes in chemotaxis and promoting endothelial cell migration and tube formation
Slit2 might promote the pathogenesis of LN by affecting various cell dysfunction in addition to leukocyte infiltration
In SSC vascular involvement is a primary event characterized by vascular tone dysfunction and microcirculatory abnormalities Many classes of guidance molecules such as members of the secreted glycoproteins Slits and their Roundabout Robo receptors play critical roles in angiogenesis Among these Robo1 and Robo4 are expressed in endothelial cells
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None