Ignite Creation Date:
2024-05-05 @ 5:29 PM
Last Modification Date:
2024-10-26 @ 9:32 AM
Study NCT ID:
NCT00462722
Status:
COMPLETED
Last Update Posted:
2015-11-01
First Post:
2007-04-17
Brief Title:
Myogenic and Osteogenic Responses to eXercise and Ibuprofen
Sponsor:
University of Colorado Denver
Organization:
University of Colorado Denver
Study Overview
Official Title:
COX Inhibition Musculoskeletal Responses to Exercise
Status:
COMPLETED
Status Verified Date:
2015-10
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
MOXI
Brief Summary:
The purpose of this study is to determine if the use of ibuprofen blocks the benefits of exercise to build bone and muscle mass
Detailed Description:
People are advised to engage in weight-bearing physical activity to help prevent the loss of bone and muscle mass that occurs with aging There is evidence from studies of animals that non-steroidal anti-inflammatory drugs NSAIDS such as ibuprofen block some of the bone- and muscle-building effects of exercise The aim of this study is to determine whether use of ibuprofen either before or after exercise blocks the benefits of exercise training on bone and skeletal muscle in older women and men The hypothesis is that taking ibuprofen before exercise will block some of the effects of exercise training to increase bone density and muscle mass
Women and men aged 60-75 years will complete a supervised 9-month exercise training program designed to increase bone and muscle mass The training will include weight lifting and weight-bearing exercises such as jumping in place and treadmill walking up to 5 days per week Participants will be randomly assigned to take 1 of 3 study pill combinations before and after each exercise session The combinations of study pills will be placebo beforeplacebo after placebo beforeibuprofen after or ibuprofen beforeplacebo after The dose of ibuprofen will be 400 mg Bone density of the hip and spine body composition total body muscle and fat and markers of bone turnover in the blood will be measured before and after 45 and 9 months of training Muscle cross-sectional area of the thigh will be measured by CT before and after 9 months of training A subset of participants will have biopsies of the thigh muscle before and after training to measure proteins and genes associated with muscle build-up and breakdown
Volunteers who do not use ibuprofen aspirin or acetaminophen more than 3 days per month will be enrolled People with intolerance to ibuprofen or related drugs cardiovascular disease or orthopedic problems that limit exercise will be excluded from the study
Women and men aged 60-75 years will complete a supervised 9-month exercise training program designed to increase bone and muscle mass The training will include weight lifting and weight-bearing exercises such as jumping in place and treadmill walking up to 5 days per week Participants will be randomly assigned to take 1 of 3 study pill combinations before and after each exercise session The combinations of study pills will be placebo beforeplacebo after placebo beforeibuprofen after or ibuprofen beforeplacebo after The dose of ibuprofen will be 400 mg Bone density of the hip and spine body composition total body muscle and fat and markers of bone turnover in the blood will be measured before and after 45 and 9 months of training Muscle cross-sectional area of the thigh will be measured by CT before and after 9 months of training A subset of participants will have biopsies of the thigh muscle before and after training to measure proteins and genes associated with muscle build-up and breakdown
Volunteers who do not use ibuprofen aspirin or acetaminophen more than 3 days per month will be enrolled People with intolerance to ibuprofen or related drugs cardiovascular disease or orthopedic problems that limit exercise will be excluded from the study
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| R01AG018857 | NIH | None | httpsreporternihgovquickSearchR01AG018857 |