Ignite Creation Date:
2024-05-05 @ 5:29 PM
Last Modification Date:
2024-10-26 @ 9:32 AM
Study NCT ID:
NCT00465660
Status:
UNKNOWN
Last Update Posted:
2007-04-25
First Post:
2007-04-24
Brief Title:
Resistive Exercise for Arthritic Cartilage Health REACH
Sponsor:
University of Sydney
Organization:
University of Sydney
Study Overview
Official Title:
The Effect of 6 Month High Intensity Progressive Resistance Training on Knee Articular Cartilage Morphology in Female Osteoarthritic Patients
Status:
UNKNOWN
Status Verified Date:
2006-12
Last Known Status:
ACTIVE_NOT_RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Female subjects over the age of 40 will be recruited and randomised into a progressive resistance training PRT or sham-exercise group The PRT group will train at 80 of their peak strength using Keiser pneumatic resistance machines and progress approximately 3 per session Strength will be re-assessed fortnightly Exercises will target muscles around the hip and knee The sham-exercise group will train on the same equipment as the PRT group except hip adduction but without added resistance or progression Both groups will train 3 days per week for roughly 45 minutes for 6 months
It is hypothesised that high intensity PRT will decelerate the tibial and femoral cartilage degeneration in the knee affected most by OA
Primary Outcome
Articular cartilage morphology following 6 months high intensity progressive resistance training
Secondary Outcomes
Muscle and fat cross-sectional area CSA pre and post Muscle strength power endurance and contraction velocity pre 3 months post Medications pre 3 months post Body composition pre 3 months post Balance Physical function pre 3 months post Questionnaires pre 3 months post
Habitual exercise PASE -WOMAC index pain stiffness and functional ability
Depressive symptoms Depression Scale -Quality of life SF36
Confidence performing physical activity Ewart -Demographics
It is hypothesised that high intensity PRT will decelerate the tibial and femoral cartilage degeneration in the knee affected most by OA
Primary Outcome
Articular cartilage morphology following 6 months high intensity progressive resistance training
Secondary Outcomes
Muscle and fat cross-sectional area CSA pre and post Muscle strength power endurance and contraction velocity pre 3 months post Medications pre 3 months post Body composition pre 3 months post Balance Physical function pre 3 months post Questionnaires pre 3 months post
Habitual exercise PASE -WOMAC index pain stiffness and functional ability
Depressive symptoms Depression Scale -Quality of life SF36
Confidence performing physical activity Ewart -Demographics
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None