Ignite Creation Date:
2024-05-05 @ 11:20 AM
Last Modification Date:
2024-10-26 @ 9:04 AM
Study NCT ID:
NCT00004753
Status:
COMPLETED
Last Update Posted:
2005-06-24
First Post:
2000-02-24
Brief Title:
Long-Term Study of Cerebral Glucose Metabolism in Huntingtons Disease
Sponsor:
National Center for Research Resources NCRR
Organization:
Office of Rare Diseases ORD
Study Overview
Official Title:
None
Status:
COMPLETED
Status Verified Date:
2001-12
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
OBJECTIVES I Correlate clinical outcome with cerebral glucose metabolism in patients with Huntingtons disease HD and their at-risk relatives
II Evaluate the efficacy of cerebral glucose metabolism in observing the pathophysiologic development of HD monitoring responses to experimental therapy and predicting HD genotype
III Identify define and describe the natural history of pathophysiologic lesions in HD
IV Characterize the genotypic and phenotypic expression of the HD gene
II Evaluate the efficacy of cerebral glucose metabolism in observing the pathophysiologic development of HD monitoring responses to experimental therapy and predicting HD genotype
III Identify define and describe the natural history of pathophysiologic lesions in HD
IV Characterize the genotypic and phenotypic expression of the HD gene
Detailed Description:
PROTOCOL OUTLINE Participants are screened for Huntingtons disease including cerebral glucose metabolism assessment and genetic testing
Studies include a detailed family history and neurologic psychometric and neurobehavioral evaluations Imaging includes positron emission tomography with fluorodeoxyglucose and brain magnetic resonance imaging
A genotype assessment is performed genetic results are not disclosed to patients or relatives
Studies include a detailed family history and neurologic psychometric and neurobehavioral evaluations Imaging includes positron emission tomography with fluorodeoxyglucose and brain magnetic resonance imaging
A genotype assessment is performed genetic results are not disclosed to patients or relatives
Study Oversight
Has Oversight DMC:
Is a FDA Regulated Drug?:
Is a FDA Regulated Device?:
Is an Unapproved Device?:
Is a PPSD?:
Is a US Export?:
Is an FDA AA801 Violation?:
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| UCLA-90063784 | None | None | None |