Ignite Creation Date:
2024-05-06 @ 4:45 PM
Last Modification Date:
2024-10-26 @ 2:16 PM
Study NCT ID:
NCT05088005
Status:
COMPLETED
Last Update Posted:
2021-10-21
First Post:
2021-10-08
Brief Title:
Prognostic Biomarkers in CO Poisoning
Sponsor:
Wonju Severance Christian Hospital
Organization:
Wonju Severance Christian Hospital
Study Overview
Official Title:
Prognostic Biomarkers of Mitochondrial and Oxidative Stress in Acute Carbon Monoxide Poisoning Prospective Hyperbaric Oxygen Therapy Intervention Study
Status:
COMPLETED
Status Verified Date:
2021-10
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Mitochondrial and oxidative stress participate in the pathogenic mechanisms of carbon monoxide CO-induced toxicity Thus serum indicators of mitochondrial and oxidative stress could be useful for predicting neurocognitive prognosis of post-CO poisoning This prospective observational study of consecutive patients requiring hyperbaric oxygen therapy HBO2 for acute CO poisoning measured serum biomarkers of mitochondrial growth differentiation factor 15 GDF15 fibroblast growth factor 21 FGF21 and oxidative 8-Oxo-2-deoxyguanosine 8-OHdG and malondialdehyde MDA stresses at arrival at the emergency department 0 h and at 24 h and 7 days after HBO2 completion We evaluated neurocognitive outcomes using the Global Deterioration Scale GDS favorable 1-3 points or poor 4-7 points outcomes
Detailed Description:
Mitochondrial and oxidative stress participate in the pathogenic mechanisms of carbon monoxide CO-induced toxicity Thus serum indicators of mitochondrial and oxidative stress could be useful for predicting neurocognitive prognosis of post-CO poisoning
This prospective observational study of consecutive patients requiring hyperbaric oxygen therapy HBO2 for acute CO poisoning measured serum biomarkers of mitochondrial growth differentiation factor 15 GDF15 fibroblast growth factor 21 FGF21 and oxidative 8-Oxo-2-deoxyguanosine 8-OHdG and malondialdehyde MDA stresses at arrival at the emergency department 0 h and at 24 h and 7 days after HBO2 completion We evaluated neurocognitive outcomes using the Global Deterioration Scale GDS favorable 1-3 points or poor 4-7 points outcomes
Levels of serum mitochondrial GDF15 and FGF21 and oxidative stress 8-OHdG and MDA biomarkers pre- and post-HBO2 were compared to assess whether HBO2 reduced stress In addition we evaluated whether the blood test results correlated with the patients neurocognitive prognosis at 1 month
This prospective observational study of consecutive patients requiring hyperbaric oxygen therapy HBO2 for acute CO poisoning measured serum biomarkers of mitochondrial growth differentiation factor 15 GDF15 fibroblast growth factor 21 FGF21 and oxidative 8-Oxo-2-deoxyguanosine 8-OHdG and malondialdehyde MDA stresses at arrival at the emergency department 0 h and at 24 h and 7 days after HBO2 completion We evaluated neurocognitive outcomes using the Global Deterioration Scale GDS favorable 1-3 points or poor 4-7 points outcomes
Levels of serum mitochondrial GDF15 and FGF21 and oxidative stress 8-OHdG and MDA biomarkers pre- and post-HBO2 were compared to assess whether HBO2 reduced stress In addition we evaluated whether the blood test results correlated with the patients neurocognitive prognosis at 1 month
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None