Ignite Creation Date:
2024-05-05 @ 5:28 PM
Last Modification Date:
2024-10-26 @ 9:32 AM
Study NCT ID:
NCT00467220
Status:
COMPLETED
Last Update Posted:
2020-01-22
First Post:
2007-04-26
Brief Title:
Effect of Daily Calorie or Alternate-day Calorie Reductions on Risk for Cardiovascular Disease and Cancer
Sponsor:
University of California San Francisco
Organization:
University of California San Francisco
Study Overview
Official Title:
Effect of Daily Calorie Restriction or Alternate-day Reductions in Calorie Intake on Risk for Cardiovascular Disease and Cancer
Status:
COMPLETED
Status Verified Date:
2020-01
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
1072
Brief Summary:
The purpose of this study is to examine and compare the effects of alternate-day reductions in calorie intake or daily calorie restriction on the risk for cardiovascular disease and cancer
Detailed Description:
Overweight individuals are at greater risk for certain chronic diseases such as cardiovascular disease and cancer when compared to those who are normal weight Dietary restriction has been shown to lower the risk of these chronic diseases in overweight human subjects as well as in normal weight rodents The majority of studies examining dietary restriction protocols in rodents or humans implement daily calorie restriction CR ie where the amount of energy consumed is decreased by a certain percentage every day Another dietary restriction regimen employed although less commonly is intermittent caloric restriction or alternate-day fasting ADF ie where food is available ad-librium every other day alternating with a partial or complete caloric restriction day Recent findings suggest that ADF may modulate certain indices of disease risk to a similar extent as daily CR in animal models The effect of ADF regimens in comparison with CR regimens on disease risk has yet to be performed in human subjects however ADF protocols need not result in weight loss and would therefore be appropriate for non-obese individuals Accumulating evidence suggest that adipose tissue may play a role in modulating chronic disease risk by releasing substrates such as fatty acids or a variety of hormones including adiponectin and leptin The effect of ADF and CR on adipose tissue metabolism and hormone release remains unclear Accordingly the aim of the present study is to compare ADF regimes to CR for their effects on risk factors for cardiovascular disease and cancer and their effects on adipose tissue metabolism and hormone secretion in normal weight to modestly overweight BMI 22-27 kgm2 human subjects
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| NIH-PPG | OTHER_GRANT | National Institutes of Health | None |