Ignite Creation Date:
2024-05-06 @ 4:44 PM
Last Modification Date:
2024-10-26 @ 2:15 PM
Study NCT ID:
NCT05078203
Status:
COMPLETED
Last Update Posted:
2024-02-20
First Post:
2021-10-01
Brief Title:
Acute Cognition and Exercise
Sponsor:
University of Illinois at Urbana-Champaign
Organization:
University of Illinois at Urbana-Champaign
Study Overview
Official Title:
Acute Exercise and Cognitive Function Examining the Role of Weight Status and Exercise-Induced Myokines
Status:
COMPLETED
Status Verified Date:
2024-02
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
ACE
Brief Summary:
The central hypothesis is that while both groups will benefit from the exercise session participants with obesity will exhibit greater gains in cognitive control relative to healthy weight adults Additionally it is anticipated that the benefits of a single bout of exercise for cognitive control will be mediated by changes in exercise-induced myokines These hypotheses will be tested by accomplishing three aims
Aim 1 Elucidate the changes in cognitive control following an acute bout of exercise relative to a sedentary condition in persons with and without obesity
Aim 2 To examine the effect of a single bout of exercise relative to a sedentary condition on myokines known to have neuroprotective effects ie BDNF and CTSB in both healthy weight and individuals with obesity
Aim 3 To link changes in exercise-induced myokines ie BDNF and CTSB to changes in cognitive function following a single bout of exercise
Aim 1 Elucidate the changes in cognitive control following an acute bout of exercise relative to a sedentary condition in persons with and without obesity
Aim 2 To examine the effect of a single bout of exercise relative to a sedentary condition on myokines known to have neuroprotective effects ie BDNF and CTSB in both healthy weight and individuals with obesity
Aim 3 To link changes in exercise-induced myokines ie BDNF and CTSB to changes in cognitive function following a single bout of exercise
Detailed Description:
18 adults with healthy weight BMI 185-250kgm2 and 18 adults with obesity BMI 300kgm2 will be asked to complete a counter-balanced crossover trial After initial baseline testing participants will be asked to complete either an acute exercise bout or sedentary control session in a counter-balanced order A cognitive testing battery accompanied by an electroencephalogram EEG will be administered following each session Blood samples will be collected prior to during and following each throughout each testing condition
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None