Ignite Creation Date:
2024-05-05 @ 5:28 PM
Last Modification Date:
2024-10-26 @ 9:32 AM
Study NCT ID:
NCT00464997
Status:
UNKNOWN
Last Update Posted:
2007-04-24
First Post:
2007-04-23
Brief Title:
The Effect of Low Dose Aspirin on the Pharmacokinetics of Methotrexate
Sponsor:
Tel-Aviv Sourasky Medical Center
Organization:
Tel-Aviv Sourasky Medical Center
Study Overview
Official Title:
The Effect of Low Dose Aspirin on the Pharmacokinetics of Methotrexate
Status:
UNKNOWN
Status Verified Date:
2007-04
Last Known Status:
NOT_YET_RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
High dose aspirin have been shown to increase the level of Methotrexat in patients with Rheumatoid Arthritis However most of RA patients are not currently treated with high dose aspirin On the other hand they frequently receive treatment with low dose aspirin The effect of low dose aspirin on the levels of Methotrexate is not well known Thereforethe purpose of this study is to assess the effect of low dose aspirin on the levels of methotrexate
Detailed Description:
Thirty Rheumatoid Arthritis patients currently treated with low dose methotrexate MTX will participate in this study On the day of intake of methotrexate the patients will receive 10 mg of MTX Serum levels of MTX will be measured at time 030 90 120 minutes and after 12 and 24 hours
Two weeks later the patients will be recommended to take 100 mg aspirind during a week The levels of MTX will be measured after a week of treatment in a way similar to a week before
Two weeks later the patients will be recommended to take 100 mg aspirind during a week The levels of MTX will be measured after a week of treatment in a way similar to a week before
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None