Ignite Creation Date:
2024-05-06 @ 4:43 PM
Last Modification Date:
2024-10-26 @ 2:15 PM
Study NCT ID:
NCT05069311
Status:
COMPLETED
Last Update Posted:
2022-08-10
First Post:
2021-09-23
Brief Title:
Effects of Multimodal Analgesia on Serum MCP-1 BDNF and MiRNA-124 in Hysterectomy Surgery
Sponsor:
Udayana University
Organization:
Udayana University
Study Overview
Official Title:
Effects of Multimodal Analgesia on Monocyte Chemoattractant Protein-1 Brain-derived Neurotrophic Factor and RNA-124 Micro to Acute Pain in Patients Who Underwent Hysterectomy
Status:
COMPLETED
Status Verified Date:
2022-08
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The inflammatory process is the main mechanism in the occurrence of acute postoperative pain It is also the main risk for the development of acute pain into persistent pain Inflammation occurs in the process of peripheral sensitization and central sensitization with various inflammatory mediators Postoperatively there will be proliferation and activation of microglia and astrocytes which will then activate inflammatory receptors and signaling cascades of neurotransmitters cytokines and chemokines There has been a lot of clinical research evidence that multimodal analgesia can adequately treat acute pain and can prevent the development of acute postoperative pain into persistent pain and chronic postoperative pain but the molecular mechanisms are not fully understood
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None