Ignite Creation Date:
2024-05-05 @ 5:28 PM
Last Modification Date:
2024-10-26 @ 9:32 AM
Study NCT ID:
NCT00463177
Status:
COMPLETED
Last Update Posted:
2008-09-04
First Post:
2007-04-19
Brief Title:
Augmented Cerebral Pain Processing in Chronic Unexplained Pain a fMRI Study
Sponsor:
UMC Utrecht
Organization:
UMC Utrecht
Study Overview
Official Title:
Augmented Cerebral Pain Processing in Chronic Unexplained Pain a 3T Event-Related Functional MRI Study
Status:
COMPLETED
Status Verified Date:
2008-09
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Chronic unexplained pain symptoms are very common in all layers of the population but it is largely unknown what causes them This study examines the hypothesis that patients with these pain symptoms process pain abnormally in their brain TO this aim we compare patients and healthy people they receive mild pain at their painful body region and at another location Concurrently we measure brain activity with brain scans functional MRI scans With our study results we want to increase understanding of what causes chronic unexplained pain symptoms in order to find better methods of diagnosing and treating them
Detailed Description:
Background
Chronic unexplained pain is a heterogeneously defined but common and recurring clinical problem in general medical practice as well as in specialist care Chronic unexplained pain causes considerable loss of quality of life frequent absence from work and it is a common reason for health care visits From a pathophysiological point of view an augmented and self-amplifying sensitivity for physical signals such as pain as well as for other signals seems to be important This is referred to as generalised hypervigilance a specific type of sensitisation Central sensitisation mechanisms have been implied in several pain syndromes In our own psychophysical pilot study we confirmed the existence of amplified pain perception in chronic unexplained pain as well as the disturbed influence of attentional processes Our study results probably reflect a general disturbance of perception not associated with a specific body location This general perceptual disturbance is expressed in a stronger fashion in the clinically affected body region Abnormal pattern of cerebral pain processing have been found in functional MRI studies in other syndromes of unknown origin such as fibromyalgia somatoform pain disorder and irritable bowel syndrome However the role of several neurobiological factors in chronic unexplained pain remain to be elucidated and to be placed in the context of the biopsychosocial model
Work plan
A 3T rapid event-related Functional MRI-experiment into the cerebral processing of experimental pain stimuli in chronic unexplained pain-patients versus healthy controls Twelve chronic unexplained pain-patients with unilateral limb pain and twelve healthy control subjects experience painful and non-painful electrical stimuli on the painful limb whilst the attentional state of the subject is controlled With functional MRI we record the pain-related cerebral activations and compare them between groups in order to characterise the cerebral correlates of altered pain processing in chronic unexplained pain
Chronic unexplained pain is a heterogeneously defined but common and recurring clinical problem in general medical practice as well as in specialist care Chronic unexplained pain causes considerable loss of quality of life frequent absence from work and it is a common reason for health care visits From a pathophysiological point of view an augmented and self-amplifying sensitivity for physical signals such as pain as well as for other signals seems to be important This is referred to as generalised hypervigilance a specific type of sensitisation Central sensitisation mechanisms have been implied in several pain syndromes In our own psychophysical pilot study we confirmed the existence of amplified pain perception in chronic unexplained pain as well as the disturbed influence of attentional processes Our study results probably reflect a general disturbance of perception not associated with a specific body location This general perceptual disturbance is expressed in a stronger fashion in the clinically affected body region Abnormal pattern of cerebral pain processing have been found in functional MRI studies in other syndromes of unknown origin such as fibromyalgia somatoform pain disorder and irritable bowel syndrome However the role of several neurobiological factors in chronic unexplained pain remain to be elucidated and to be placed in the context of the biopsychosocial model
Work plan
A 3T rapid event-related Functional MRI-experiment into the cerebral processing of experimental pain stimuli in chronic unexplained pain-patients versus healthy controls Twelve chronic unexplained pain-patients with unilateral limb pain and twelve healthy control subjects experience painful and non-painful electrical stimuli on the painful limb whilst the attentional state of the subject is controlled With functional MRI we record the pain-related cerebral activations and compare them between groups in order to characterise the cerebral correlates of altered pain processing in chronic unexplained pain
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None