Ignite Creation Date:
2024-05-06 @ 4:42 PM
Last Modification Date:
2024-10-26 @ 2:15 PM
Study NCT ID:
NCT05068271
Status:
RECRUITING
Last Update Posted:
2023-11-27
First Post:
2021-07-19
Brief Title:
Multi-Domain Exercise and Memory in Adults Relative to ApoE Genotype A fMRI Study
Sponsor:
National Taiwan Normal University
Organization:
National Taiwan Normal University
Study Overview
Official Title:
Effects of Multi-Domain Exercise Intervention on Memory Performance in Healthy Adults With and Without ApoE e4 Allele A fMRI Study
Status:
RECRUITING
Status Verified Date:
2023-11
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The current project utilizes a single-blinded double arm 6-month randomized controlled trial to assess the effects of a multi-domain exercise program on memory performance as well as cortical activities during the memory tasks in cognitively intact adults ie 45-70 years In addition the potential moderator role of apolipoprotein epsilon-4 ApoE e4 status and the mediator role of the brain-derived neurotrophic factor BDNF will be explored
Detailed Description:
Aging has been adversely associated with the deterioration of cognitive and brain functions Most research on the effects of regular exercise on cognitive and brain functions has been focused on exercise programs with a single mode of exercise Studies focusing on the effects of exercise programs with multi-domains on cognitive function and cortical functionality are sparse in late-middle-aged and older adults In addition while growing evidence has revealed the beneficial effects of regular exercise on cognitive function scientific evidence regarding the effects of multi-domain exercise programs on cognitive function and brain function in late-middle-aged and older adults who are with or without the genetic risk for Alzheimers disease AD is scarce Lastly the potential mediator role of the brain-derived neurotrophic factor BDNF in individuals is required to be explored
In the current study a single-blinded double arm 6-month randomized controlled trial has been utilized to assess the effects of a multi-domain exercise program containing multiple physical fitness components meditation and social interaction on memory as well as cortical functionalities during the memory tasks in cognitively intact adults ie 45-70 years Specifically the project aims to examine 1 the causal links between a multi-domain exercise program composed of various physical fitness components meditation and social interaction against a control group on the memory performance in cognitively intact adults aged between 45 and 70 years with or without a genetic risk for AD 2 the cortical functionality through functional images collected through a series of functional magnetic resonance images fMRI and 3 the potential influence of apolipoprotein epsilon-4 ApoE e4 and BDNF on the effects of exercise
One hundred eligible individuals will participate in the current study and will be randomly assigned into either the 6-month multi-domain exercise group exercise group or the online educational course group control group
All participants physical fitness cognitive function and cortical functionalities via fMRI scanning will be assessed at the Baseline Baseline-Assessments and at the cessation of the 6-month intervention Post-Assessments The potential moderating role of ApoE genotypes and the mediation role of BDNF will be explored Participation in this study will take approximately 7 months
In the current study a single-blinded double arm 6-month randomized controlled trial has been utilized to assess the effects of a multi-domain exercise program containing multiple physical fitness components meditation and social interaction on memory as well as cortical functionalities during the memory tasks in cognitively intact adults ie 45-70 years Specifically the project aims to examine 1 the causal links between a multi-domain exercise program composed of various physical fitness components meditation and social interaction against a control group on the memory performance in cognitively intact adults aged between 45 and 70 years with or without a genetic risk for AD 2 the cortical functionality through functional images collected through a series of functional magnetic resonance images fMRI and 3 the potential influence of apolipoprotein epsilon-4 ApoE e4 and BDNF on the effects of exercise
One hundred eligible individuals will participate in the current study and will be randomly assigned into either the 6-month multi-domain exercise group exercise group or the online educational course group control group
All participants physical fitness cognitive function and cortical functionalities via fMRI scanning will be assessed at the Baseline Baseline-Assessments and at the cessation of the 6-month intervention Post-Assessments The potential moderating role of ApoE genotypes and the mediation role of BDNF will be explored Participation in this study will take approximately 7 months
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None