Ignite Creation Date:
2024-05-05 @ 5:28 PM
Last Modification Date:
2024-10-26 @ 9:32 AM
Study NCT ID:
NCT00465348
Status:
WITHDRAWN
Last Update Posted:
2012-10-25
First Post:
2007-04-24
Brief Title:
The Antioxidant Effect of Routine Vascular Therapy for Normal Tension Glaucoma Patients
Sponsor:
University Hospital Basel Switzerland
Organization:
University Hospital Basel Switzerland
Study Overview
Official Title:
The Antioxidant Effect of Routine Vascular Therapy for Normal Tension Glaucoma Patients
Status:
WITHDRAWN
Status Verified Date:
2012-10
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
investigator withdrew
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
To quantify oxidative stress in circulating leukocytes of normal tension glaucoma patients prior to and one month after routine vascular therapy
Detailed Description:
There are two accepted medical modalities for glaucoma treatment The first is a local application of an intraocular pressure IOP lowering drug The second is the application of systemic drugs to improve vascular regulation In the present study we would like to investigate whether this systemic form of treatment in addition to improving blood flow also reduces systemic oxidative stress
Vascular dysregulation is one of the major risk factors for glaucoma in particular for normal tension glaucoma NTG In glaucoma patients blood flow is on average reduced not only in the eye but also in various other organs of the body for example in the fingers Such a systemic dysregulation leads to disturbed autoregulation and thereby to an unstable oxygen supply in the eyeThis in turn leads to the formation of reactive oxygen species ROS These ROS are capable of damaging cells such as white blood cells this damage however is reversible as nature has provided us with mechanisms to repair this damage This reversible damage brought about by ROS which is constantly being repaired in our body is an indication for oxidative stress Oxidative stress plays an important role in the pathogenesis of glaucoma
The indications for oxidative stress can be quantified in our laboratory by the method of comet assay also known as single cell gel electrophoresis
Vascular dysregulation is one of the major risk factors for glaucoma in particular for normal tension glaucoma NTG In glaucoma patients blood flow is on average reduced not only in the eye but also in various other organs of the body for example in the fingers Such a systemic dysregulation leads to disturbed autoregulation and thereby to an unstable oxygen supply in the eyeThis in turn leads to the formation of reactive oxygen species ROS These ROS are capable of damaging cells such as white blood cells this damage however is reversible as nature has provided us with mechanisms to repair this damage This reversible damage brought about by ROS which is constantly being repaired in our body is an indication for oxidative stress Oxidative stress plays an important role in the pathogenesis of glaucoma
The indications for oxidative stress can be quantified in our laboratory by the method of comet assay also known as single cell gel electrophoresis
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None