Ignite Creation Date:
2024-05-06 @ 4:41 PM
Last Modification Date:
2024-10-26 @ 2:14 PM
Study NCT ID:
NCT05059431
Status:
COMPLETED
Last Update Posted:
2021-09-28
First Post:
2021-09-19
Brief Title:
The Effect of Human Prostate Tissue on Platelet Activation
Sponsor:
Tri-Service General Hospital
Organization:
Tri-Service General Hospital
Study Overview
Official Title:
The Effect of Human Prostate Tissue on Platelet CD40 Ligand Toll-like Receptor 4 P-selectin and Platelet-Leukocyte Aggregation an In Vitro Study
Status:
COMPLETED
Status Verified Date:
2021-09
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Transurethral resection of the prostate TURP is a common and standard urological surgical procedure for managing benign prostatic hyperplasia BPH Although surgical technology improved in recent decades severe complications such as TURP syndrome hematuria and postoperative hemorrhage were still considerable Coagulopathy is one of rare but devastating complication which may contribute to bleeding during and after TURP Although the exact pathophysiological condition of coagulopathy is not clear there are several possible mechanisms of TURP associated coagulopathy including urokinase- u-PA and tissue-type plasminogen activator t-PA-related fibrinolysis absorption of irrigating fluid associated dilutional coagulopathy release of prostatic particles rich in tissue thromboplastins into the circulation causing secondary fibrinolysis and disseminated intravascular coagulopathy DIC sepsis with DIC associated with bacteria entering the circulation due to prostatic venous sinuses opening and the using of high pressure irrigation On the other hand platelet are essential to hemostasis and thrombosis and its activation also contributes to leukocyte recruitment and DIC Furthermore previous studies demonstrated that activated platelets could express TLR4 CD40L P-selectin and induce platelet-leukocyte aggregation PLA which were considered important for systemic inflammatory responses and DIC development Currently no study investigating the association of prostate particle and platelet activation Here we tested the hypothesis that prostate tissue may induce inflammatory responses through platelet activation by measuring the expression of TLR4 CD40L P-selectin and PLA on platelets
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None