Viewing Study NCT00457847



Ignite Creation Date: 2024-05-05 @ 5:27 PM
Last Modification Date: 2024-10-26 @ 9:32 AM
Study NCT ID: NCT00457847
Status: RECRUITING
Last Update Posted: 2024-07-05
First Post: 2007-04-05

Brief Title: Identifying Genetic Characteristics That Increase Risk of Primary Graft Dysfunction Following Lung Transplantation
Sponsor: University of Pennsylvania
Organization: University of Pennsylvania

Study Overview

Official Title: Genetics of Primary Graft Dysfunction
Status: RECRUITING
Status Verified Date: 2024-07
Last Known Status: None
Delayed Posting: No
If Stopped, Why?: Not Stopped
Has Expanded Access: False
If Expanded Access, NCT#: N/A
Has Expanded Access, NCT# Status: N/A
Acronym: None
Brief Summary: Primary graft dysfunction PGD is a severe lung injury that can occur in the days following lung transplant surgery The purpose of this study is to identify genetic factors that may put someone at risk for developing PGD
Detailed Description: PGD is a severe complication that affects up to 25 of lung transplant patients following surgery Pulmonary edema which is an abnormal build-up of fluid in the lungs and hypoxemia which is low blood oxygen levels are two common symptoms that individuals with PGD experience Treatment for this condition is often expensive and it is the leading cause of death following lung transplant Many potential donors and recipients are considered unsuitable for lung transplant because of concern for the development of PGD Therefore the ability to accurately predict which individuals are at risk for developing PGD may allow more lung transplants to be performed Specific characteristics in both lung donors and recipients may play an important role in determining the risk of PGD For example genetic variations in how the body deals with harmful chemicals called oxidants may be associated with the development of PGD The purpose of this study is to identify the specific genetic biomarkers in donors and recipients that put individuals at risk for developing PGD following a lung transplant

This study will enroll individuals who are undergoing lung transplantation Blood samples will be collected from lung donors and from participants prior to surgery immediately following surgery and 24 hours after surgery Study researchers will monitor participants for 72 hours following surgery for symptoms of PGD There will be no additional study visits

Study Oversight

Has Oversight DMC: None
Is a FDA Regulated Drug?: None
Is a FDA Regulated Device?: None
Is an Unapproved Device?: None
Is a PPSD?: None
Is a US Export?: None
Is an FDA AA801 Violation?: None
Secondary IDs
Secondary ID Type Domain Link
R01HL081619 NIH None httpsreporternihgovquickSearchR01HL081619