Ignite Creation Date:
2024-05-05 @ 5:27 PM
Last Modification Date:
2024-10-26 @ 9:32 AM
Study NCT ID:
NCT00458419
Status:
COMPLETED
Last Update Posted:
2007-11-02
First Post:
2007-04-08
Brief Title:
Role of Endorphins in the Perception of Dyspnea in Patients With Chronic Obstructive Pulmonary Disease
Sponsor:
Dartmouth-Hitchcock Medical Center
Organization:
Dartmouth-Hitchcock Medical Center
Study Overview
Official Title:
Role of Endorphins in the Perception of Dyspnea in Patients With Chronic Obstructive Pulmonary Disease
Status:
COMPLETED
Status Verified Date:
2007-10
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Endorphins are naturally occurring narcotic substances that are released when individuals perform exercise The hypothesis of the study is that endorphins reduce the severity of breathlessness during exercise in patients with chronic obstructive pulmonary disease COPD The initial five visits include familiarization and validation of a computerized system for patients to report dyspnea and leg discomfort continuously during exercise testing
At Visits 6 and 7 blood is drawn to measure serum endorphin levels pre-exercise end exercise and 30 minutes after exercise Normal saline or naloxone is given intravenously 5 minutes prior to exercise in a double-blinded design The primary outcome is the slope of oxygen consumption - dyspnea
At Visits 6 and 7 blood is drawn to measure serum endorphin levels pre-exercise end exercise and 30 minutes after exercise Normal saline or naloxone is given intravenously 5 minutes prior to exercise in a double-blinded design The primary outcome is the slope of oxygen consumption - dyspnea
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None