Ignite Creation Date:
2024-05-06 @ 4:35 PM
Last Modification Date:
2024-10-26 @ 2:12 PM
Study NCT ID:
NCT05031520
Status:
ACTIVE_NOT_RECRUITING
Last Update Posted:
2024-05-02
First Post:
2021-08-24
Brief Title:
PericOronary INflammaTion in Non-Obstructive Coronary Artery Disease
Sponsor:
NYU Langone Health
Organization:
NYU Langone Health
Study Overview
Official Title:
A Single Center Study of Perivascular Coronary Inflammation in Patients With Myocardial Ischemia or Infarction With Non-Obstructive Coronary Arteries
Status:
ACTIVE_NOT_RECRUITING
Status Verified Date:
2024-09
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
POINT-NOCAD
Brief Summary:
Among patients with ischemic heart disease who are referred for coronary angiography a substantial proportion have non-obstructive coronary artery disease CAD Myocardial infarction MI with non-obstructive coronary artery disease MINOCA accounts for 5-20 of patients with MI and preferentially affects women MINOCA pathogenesis is varied and may include atherosclerotic plaque rupture plaque erosion with thrombosis vasospasm embolization dissection or a combination of mechanisms Other patients may have clinically unrecognized myocarditis or takotsubo syndrome masquerading as MI Among patients referred for coronary angiography for the evaluation of stable ischemic heart disease non-obstructive CAD is present in up to 30 of men and 60 of women Stable ischemia with non-obstructive coronary arteries INOCA may be due to coronary microvascular dysfunction in up to 40 of these patients Our understanding of mechanisms of MINOCA and INOCA remain incomplete Coronary inflammation has been hypothesized as a potential mechanism contributing to coronary spasm in MINOCA and microvascular disease in INOCA
Detailed Description:
The PericOronary INflammaTion in Non-Obstructive Coronary Artery Disease POINT-NOCAD study is a single-center diagnostic observational study enrolling men and women with MINOCA or INOCA who are planned to undergo or underwent clinically indicated coronary angiography The research plan is to evaluate coronary inflammation as measured by the perivascular coronary fat attenuation index from non-invasive coronary computed tomography angiography CCTA in patients with MINOCA and INOCA
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None