Ignite Creation Date:
2024-05-06 @ 4:35 PM
Last Modification Date:
2024-10-26 @ 2:12 PM
Study NCT ID:
NCT05031195
Status:
COMPLETED
Last Update Posted:
2022-03-25
First Post:
2021-08-29
Brief Title:
Prognostic Impact of NLR PLR and MPV in Patients Undergoing AAA Open Repair
Sponsor:
Gangnam Severance Hospital
Organization:
Gangnam Severance Hospital
Study Overview
Official Title:
Preoperative Neutrophil to Lymphocyte Ratio Platelet to Lymphocyte Ratio and Mean Platelet Volume as Predictors of 1 Year Mortality in Patients Undergoing an Open Repair of Abdominal Aortic Aneurysms a Retrospective Study
Status:
COMPLETED
Status Verified Date:
2022-03
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Abdominal aortic aneurysm AAA is a multifactorial degenerative disorder which if untreated might lead to catastrophic complications The treatment for AAA includes open and endovascular repair both of which carry a significant degree of risk Thus researchers have performed several studies addressing simple and readily available risk stratification markers such as complete blood count in patients undergoing open AAA repair
The neutrophil to lymphocyte ratio NLR has been frequently used as a marker of systemic inflammatory response which reflects neutrophilia and lymphopenia The primary pathophysiology of AAA involves chronic inflammation in the aortic wall and atherosclerosis accompanied with thrombosis NLR was proposed as a fair indicator for poor prognosis in patients with AAA The mean platelet volume MPV is the marker of platelet activation and an indicator of the activation of thrombus formation Moreover it is reportedly associated with the prognosis of patients with cardiovascular diseases Moreover the platelet to lymphocyte ratio PLR suggests thrombosis and inflammation and indicates a high risk of cardiovascular events in various groups of patients The PLR is associated with poor prognosis following AAA repair Despite accumulating evidence for the prognostic value of white blood cell counts in abdominal aortic aneurysm few studies have investigated the value of these parameters including NLR MPV and PLR in patients undergoing AAA open repair
The investigators aimed to investigate if preoperative neutrophil to lymphocyte ratio NLR platelet to lymphocyte ratio PLR or mean platelet volume MPV could be used to predict 1-year mortality in patients undergoing open abdominal aortic aneurysm AAA repair
The neutrophil to lymphocyte ratio NLR has been frequently used as a marker of systemic inflammatory response which reflects neutrophilia and lymphopenia The primary pathophysiology of AAA involves chronic inflammation in the aortic wall and atherosclerosis accompanied with thrombosis NLR was proposed as a fair indicator for poor prognosis in patients with AAA The mean platelet volume MPV is the marker of platelet activation and an indicator of the activation of thrombus formation Moreover it is reportedly associated with the prognosis of patients with cardiovascular diseases Moreover the platelet to lymphocyte ratio PLR suggests thrombosis and inflammation and indicates a high risk of cardiovascular events in various groups of patients The PLR is associated with poor prognosis following AAA repair Despite accumulating evidence for the prognostic value of white blood cell counts in abdominal aortic aneurysm few studies have investigated the value of these parameters including NLR MPV and PLR in patients undergoing AAA open repair
The investigators aimed to investigate if preoperative neutrophil to lymphocyte ratio NLR platelet to lymphocyte ratio PLR or mean platelet volume MPV could be used to predict 1-year mortality in patients undergoing open abdominal aortic aneurysm AAA repair
Detailed Description:
The investigators will retrospectively review medical records who underwent open abdominal aortic aneurysm repair between Jan 2008 and July 2019 The investigators will divide the patients into two groups according to the occurrence of 1-yr mortality Then the investigators compare complete blood count including NLR PLR and MPV between the groups Furthermore the patient will be divided into tertiles according to the preoperative NLR PLR and MPV values to compare the incidence of 1-yr mortality and other morbidities Multivariable logistic regression analysis will be performed to investigate possible prognostic factor for 1-yr mortality in these patients
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None