Ignite Creation Date:
2024-05-06 @ 4:35 PM
Last Modification Date:
2024-10-26 @ 2:12 PM
Study NCT ID:
NCT05032014
Status:
UNKNOWN
Last Update Posted:
2021-10-25
First Post:
2021-06-23
Brief Title:
Probiotics Enhance the Treatment of PD-1 Inhibitors in Patients With Liver Cancer
Sponsor:
Jiangxi Provincial Cancer Hospital
Organization:
Jiangxi Provincial Cancer Hospital
Study Overview
Official Title:
Probiotics Enhance the Treatment of PD-1 Inhibitors in Patients With Liver Cancer
Status:
UNKNOWN
Status Verified Date:
2021-10
Last Known Status:
RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Human microbes have been called the second genome of humanityOn May 132016the White House launched the National Microbiome Initiative NMI with an estimated investment of us 521 million to elevate microbiome research to a national strategic status The gut is the largest microecological environment in the human body The research in the field of intestinal microbiome has become one of the most advanced and hot research directions in the scientific field of the world today At present more than 50 diseases have been found to be related to intestinal microbiome disorders Pd-1 programmed death receptor 1 is an important immunosuppressive moleculeIt regulates the immune system and promotes tolerance by down-regulating the immune systems response to human cells and by suppressing T cell inflammatory activity In the past the research team and colleagues in related fields have found a strong correlation between Gut Microbiome and the efficacy of anti-PD-1 immunotherapy in cancer patientsThis protects against autoimmune diseases but it also prevents the immune system from killing cancer cells As more and more scientific evidence shows that intervention of human intestinal flora may improve the efficacy of anti-PD-1 immunotherapy in tumor patients intestinal flora as the most effective way to intervene human intestinal flora has been mentioned by many research institutions and international drug manufacturers in combination with anti-PD-1Our previous study showed that the abundance of beneficial bacteria such as lactic acid bacteria bifidobacteria and Akkermansia Muciniphila was significantly correlated with pD-1 inhibitor response and regulating the intestinal flora content could improve the effect of PD-1 inhibitor on mouse tumors indicating that microbial flora was involved in regulating cancer immunotherapy
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None