Ignite Creation Date:
2024-05-06 @ 4:32 PM
Last Modification Date:
2024-10-26 @ 2:11 PM
Study NCT ID:
NCT05014529
Status:
RECRUITING
Last Update Posted:
2021-09-24
First Post:
2021-08-14
Brief Title:
The Continuous Positive Airway Pressure Effect on Rho-associated Coiled-coil Containing Kinases Activity
Sponsor:
Chang Gung Memorial Hospital
Organization:
Chang Gung Memorial Hospital
Study Overview
Official Title:
The Continuous Positive Airway Pressure Effect on Rho-associated Coiled-coil Containing Kinases Activity and Left Ventricle Mass in Obstructive Sleep Apnea-hypopnea Syndrome
Status:
RECRUITING
Status Verified Date:
2021-09
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The ROCK Rho-associated coiled-coil containing kinases play a critical role in the pathogenesis of cardiovascular diseases and left ventricle hypertrophy LVH ROCK activity can be used as a clinical biomarker for the diagnosis and monitoring of cardiovascular disorders Obstructive sleep apnea OSA increase cardiovascular disease and LVH Continuous positive airway pressure CPAP is the standard therapy for OSA This study investigate the effect of CPAP on ROCK activity and left ventricle mass
Detailed Description:
The ROCK were discovered as downstream targets of Ras homologous A and regulate various important cellular functions including proliferation migration adhesion and apoptosis They play a critical role in the pathogenesis of cardiovascular diseases including cardiac fibrosis hypertrophy and remodeling ROCK activity can be detected in human circulating leukocytes and could potentially be used as a clinical biomarker for the diagnosis and monitoring of cardiovascular disorders It has been proven that higher ROCK activity is present in left ventricle hypertrophy LVH patients than those without LVH Obstructive sleep apneaOSA is characterized by recurrent collapse of the pharyngeal airway during sleep that leads to intermittent nocturnal hypoxia resulting in a broad range of cardiovascular morbidities including coronary artery disease heart failure cardiac arrhythmias and LVH Continuous positive airway pressure CPAP is the standard therapy for OSA and several studies have shown that it can effectively reduce cardiovascular disease but the effect of CPAP on left ventricle mass reduction is still uncertain Previous studies demonstrated that patients with OSA had higher circulatory ROCK activity than those without OSA but the role of CPAP on ROCK activity is not known The circulatory leukocyte ROCK activity may be used as a clinical biomarker for cardiovascular disease and ROCK inhibitors may be used in the future as a treatment OSA and CPAP treatment may also affect ROCK activity the relationship between CPAP treatment cardiac hypertrophy and ROCK activity is important and should be clarified Therefore the main purpose of our study is to evaluate the effect of CPAP on ROCK activity and left ventricle mass
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None