Ignite Creation Date:
2024-05-05 @ 5:26 PM
Last Modification Date:
2024-10-26 @ 9:31 AM
Study NCT ID:
NCT00452049
Status:
UNKNOWN
Last Update Posted:
2012-05-30
First Post:
2007-03-23
Brief Title:
The Effect of Parathyroidectomy on Renal Function Endothelial Function and Blood Pressure
Sponsor:
Universitaire Ziekenhuizen KU Leuven
Organization:
Universitaire Ziekenhuizen KU Leuven
Study Overview
Official Title:
Observational Study to Evaluate the Effect of Parathyroidectomy on Renal Function Endothelial Function and Blood Pressure
Status:
UNKNOWN
Status Verified Date:
2012-05
Last Known Status:
RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Secondary hyperparathyroidism HPT is a known complication of chronic renal failure Elevated concentrations of parathyroid hormone PTH play a role not only in the pathogenesis of renal bone disease but also in the development of cardiovascular risk factors such as disturbed lipid metabolism glucose intolerance and hypertension HPT is also known to play an important role in the development of structural abnormalities of both large arteries and the heart left ventricular hypertrophy interstitial fibrosis In the last couple of years there has been increasing evidence from animal studies that the endothelium is a target organ of PTH
Hypothesis PTH has clinically relevant effects on renal hemodynamics renal function and endothelial function
Aims
1 To evaluate the effect of parathyroidectomy PTX on renal hemodynamics in stable renal transplant recipients
2 To evaluate the effect of PTX on endothelial function in stable renal transplant recipientschronic kidney disease CKD stage 5 patients
3 To evaluate the effect of PTX on blood pressure in stable renal transplant recipientsCKD stage 5 patients
Hypothesis PTH has clinically relevant effects on renal hemodynamics renal function and endothelial function
Aims
1 To evaluate the effect of parathyroidectomy PTX on renal hemodynamics in stable renal transplant recipients
2 To evaluate the effect of PTX on endothelial function in stable renal transplant recipientschronic kidney disease CKD stage 5 patients
3 To evaluate the effect of PTX on blood pressure in stable renal transplant recipientsCKD stage 5 patients
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None